GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus
In the nervous system, there are a wide variety of neuronal cell types that have morphologically, physiologically, and histochemically different characteristics. These various types of neurons can be classified into two groups: excitatory and inhibitory neurons. The elaborate balance of the activiti...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/921732 |
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| author | Kei Hori Mikio Hoshino |
| author_facet | Kei Hori Mikio Hoshino |
| author_sort | Kei Hori |
| collection | DOAJ |
| description | In the nervous system, there are a wide variety of neuronal cell types that have morphologically, physiologically, and histochemically different characteristics. These various types of neurons can be classified into two groups: excitatory and inhibitory neurons. The elaborate balance of the activities of the two types is very important to elicit higher brain function, because its imbalance may cause neurological disorders, such as epilepsy and hyperalgesia. In the central nervous system, inhibitory neurons are mainly represented by GABAergic ones with some exceptions such as glycinergic. Although the machinery to specify GABAergic neurons was first studied in the telencephalon, identification of key molecules, such as pancreatic transcription factor 1a (Ptf1a), as well as recently developed genetic lineage-tracing methods led to the better understanding of GABAergic specification in other brain regions, such as the spinal cord, the cerebellum, and the cochlear nucleus. |
| format | Article |
| id | doaj-art-63633164ffc14548b5654fe94fda1f31 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-63633164ffc14548b5654fe94fda1f312025-02-03T01:11:13ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/921732921732GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear NucleusKei Hori0Mikio Hoshino1Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogahahigashi, Kodaira, Tokyo 187-8502, JapanDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogahahigashi, Kodaira, Tokyo 187-8502, JapanIn the nervous system, there are a wide variety of neuronal cell types that have morphologically, physiologically, and histochemically different characteristics. These various types of neurons can be classified into two groups: excitatory and inhibitory neurons. The elaborate balance of the activities of the two types is very important to elicit higher brain function, because its imbalance may cause neurological disorders, such as epilepsy and hyperalgesia. In the central nervous system, inhibitory neurons are mainly represented by GABAergic ones with some exceptions such as glycinergic. Although the machinery to specify GABAergic neurons was first studied in the telencephalon, identification of key molecules, such as pancreatic transcription factor 1a (Ptf1a), as well as recently developed genetic lineage-tracing methods led to the better understanding of GABAergic specification in other brain regions, such as the spinal cord, the cerebellum, and the cochlear nucleus.http://dx.doi.org/10.1155/2012/921732 |
| spellingShingle | Kei Hori Mikio Hoshino GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus Neural Plasticity |
| title | GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus |
| title_full | GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus |
| title_fullStr | GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus |
| title_full_unstemmed | GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus |
| title_short | GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus |
| title_sort | gabaergic neuron specification in the spinal cord the cerebellum and the cochlear nucleus |
| url | http://dx.doi.org/10.1155/2012/921732 |
| work_keys_str_mv | AT keihori gabaergicneuronspecificationinthespinalcordthecerebellumandthecochlearnucleus AT mikiohoshino gabaergicneuronspecificationinthespinalcordthecerebellumandthecochlearnucleus |