Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants

Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants

Abstract Objective To explore IL11 co-expression profiles in our previously reported RNA-sequencing dataset of OA articular cartilage, in interaction with IL6, and to investigate the effects of hrIL11 administration as potential therapeutic strategy for OA articular cartilage using our biomimetic ag...

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Bibliographic Details
Main Authors: Margo Tuerlings, Evelyn Houtman, Elisa J.H. Muusers, Janneke Simon, Maurice W. de Haan, Ilja Boone, Yolande F.M. Ramos, Rachid Mahdad, Ingrid Meulenbelt
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
IL11
Osteochondral explants
Online Access:https://doi.org/10.1186/s13075-025-03480-4
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