Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens
Dental caries is considered one of the most prevalent oral diseases worldwide, with a high rate of morbidity among populations. It is a chronic infectious disease with a multifactorial etiology that leads to the destruction of the dental tissues. Due to their antimicrobial, anti-inflammatory, antifu...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2022/9602325 |
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| author | Omnia Ahmed Nicole R. S. Sibuyi Adewale O. Fadaka Abram M. Madiehe Ernest Maboza Annette Olivier Mervin Meyer Greta Geerts |
| author_facet | Omnia Ahmed Nicole R. S. Sibuyi Adewale O. Fadaka Abram M. Madiehe Ernest Maboza Annette Olivier Mervin Meyer Greta Geerts |
| author_sort | Omnia Ahmed |
| collection | DOAJ |
| description | Dental caries is considered one of the most prevalent oral diseases worldwide, with a high rate of morbidity among populations. It is a chronic infectious disease with a multifactorial etiology that leads to the destruction of the dental tissues. Due to their antimicrobial, anti-inflammatory, antifungal, and antioxidant properties; silver nanoparticles (AgNPs) are incorporated in dental products to help prevent infectious oral diseases. In this study, the antimicrobial effects of AgNPs synthesized using Gum Arabic extracts (GAE) were examined. The GA-AgNPs were synthesized and characterized using ultraviolet-visible (UV-Vis) spectrophotometer, dynamic light scattering (DLS), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of the GA-AgNPs was evaluated on Streptococcus sanguinis (S. sanguinis), Streptococcus mutans (S. mutans), Lactobacillus acidophilus (L. acidophilus), and Candida albicans (C. albicans) using agar disc diffusion and microdilution assays. The antibiofilm of GA-AgNPs was evaluated on the surface of human tooth enamel that had been exposed to S. mutans with and without the GA-AgNPs using scanning electron microscopy (SEM). GA-AgNPs were spherical in shape with a particle size distribution between 4 and 26 nm. The GA-AgNPs exhibited antimicrobial activity against all the tested oral microbes, with GA-AgNPs_0.4g having higher antimicrobial activity. The GA-AgNPs_0.4g inhibited S. mutans adhesion and biofilm formation on the surface of the tooth enamel. Therefore, this study supports the prospective implementation of the plant extract-mediated AgNPs in dental healthcare. |
| format | Article |
| id | doaj-art-634ea7a162984178873fadae8b797857 |
| institution | Kabale University |
| issn | 1687-479X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-634ea7a162984178873fadae8b7978572025-02-03T05:57:59ZengWileyBioinorganic Chemistry and Applications1687-479X2022-01-01202210.1155/2022/9602325Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral PathogensOmnia Ahmed0Nicole R. S. Sibuyi1Adewale O. Fadaka2Abram M. Madiehe3Ernest Maboza4Annette Olivier5Mervin Meyer6Greta Geerts7Department of Restorative DentistryDepartment of Science and Innovation (DSI) ‐ Mintek Nanotechnology Innovation Centre (NIC) Biolabels Research NodeDepartment of Science and Innovation (DSI) ‐ Mintek Nanotechnology Innovation Centre (NIC) Biolabels Research NodeDepartment of Science and Innovation (DSI) ‐ Mintek Nanotechnology Innovation Centre (NIC) Biolabels Research NodeOral and Dental Research LaboratoryOral and Dental Research LaboratoryDepartment of Science and Innovation (DSI) ‐ Mintek Nanotechnology Innovation Centre (NIC) Biolabels Research NodeDepartment of Restorative DentistryDental caries is considered one of the most prevalent oral diseases worldwide, with a high rate of morbidity among populations. It is a chronic infectious disease with a multifactorial etiology that leads to the destruction of the dental tissues. Due to their antimicrobial, anti-inflammatory, antifungal, and antioxidant properties; silver nanoparticles (AgNPs) are incorporated in dental products to help prevent infectious oral diseases. In this study, the antimicrobial effects of AgNPs synthesized using Gum Arabic extracts (GAE) were examined. The GA-AgNPs were synthesized and characterized using ultraviolet-visible (UV-Vis) spectrophotometer, dynamic light scattering (DLS), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of the GA-AgNPs was evaluated on Streptococcus sanguinis (S. sanguinis), Streptococcus mutans (S. mutans), Lactobacillus acidophilus (L. acidophilus), and Candida albicans (C. albicans) using agar disc diffusion and microdilution assays. The antibiofilm of GA-AgNPs was evaluated on the surface of human tooth enamel that had been exposed to S. mutans with and without the GA-AgNPs using scanning electron microscopy (SEM). GA-AgNPs were spherical in shape with a particle size distribution between 4 and 26 nm. The GA-AgNPs exhibited antimicrobial activity against all the tested oral microbes, with GA-AgNPs_0.4g having higher antimicrobial activity. The GA-AgNPs_0.4g inhibited S. mutans adhesion and biofilm formation on the surface of the tooth enamel. Therefore, this study supports the prospective implementation of the plant extract-mediated AgNPs in dental healthcare.http://dx.doi.org/10.1155/2022/9602325 |
| spellingShingle | Omnia Ahmed Nicole R. S. Sibuyi Adewale O. Fadaka Abram M. Madiehe Ernest Maboza Annette Olivier Mervin Meyer Greta Geerts Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens Bioinorganic Chemistry and Applications |
| title | Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens |
| title_full | Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens |
| title_fullStr | Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens |
| title_full_unstemmed | Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens |
| title_short | Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens |
| title_sort | antimicrobial effects of gum arabic silver nanoparticles against oral pathogens |
| url | http://dx.doi.org/10.1155/2022/9602325 |
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