Lung Adenocarcinoma Expressing an EML4‐ALK Fusion Transcript With Premature Stop Codons and Response to Alectinib: A Case Report

Lung Adenocarcinoma Expressing an EML4‐ALK Fusion Transcript With Premature Stop Codons and Response to Alectinib: A Case Report

ABSTRACT ALK fusions are well‐established oncogenic drivers in lung cancer, typically resulting in ALK activation through dimerization mediated by partner proteins. However, alternative mechanisms of ALK activation have also been reported. We herein report an 80‐year‐old man with metastatic lung ade...

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Bibliographic Details
Main Authors: Mami Ozaki, Hiroaki Ikushima, Masaki Suzuki, Akira Yokoyama, Kensuke Fukuda, Kousuke Watanabe, Aya Shinozaki‐Ushiku, Motohiro Kato, Tetsuo Ushiku, Hiroyuki Aburatani, Katsutoshi Oda, Hidenori Kage
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Thoracic Cancer
Subjects:
ALK
case report
comprehensive genomic profiling
lung cancer
RNA‐sequencing
Online Access:https://doi.org/10.1111/1759-7714.70146
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