False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor
123I-Metaiodobenzylguanidine (123I-MIBG) scintigraphy is a widely used functional imaging tool with a high degree of sensitivity and specificity in diagnosis of pheochromocytoma. However, rare cases of false positive reactions have been reported. A 67-year-old male patient was admitted with epigastr...
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| Format: | Article |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/164280 |
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| author | Hee Soo Jung Seok Jun Moon Yun Mi Kim Hye Rim Kang Seok Mo Lee Soo Jin Jung Seok Jin Choi Tae Kyoon Kim Min Jeong Kwon Jeong Hyun Park Soon Hee Lee |
| author_facet | Hee Soo Jung Seok Jun Moon Yun Mi Kim Hye Rim Kang Seok Mo Lee Soo Jin Jung Seok Jin Choi Tae Kyoon Kim Min Jeong Kwon Jeong Hyun Park Soon Hee Lee |
| author_sort | Hee Soo Jung |
| collection | DOAJ |
| description | 123I-Metaiodobenzylguanidine (123I-MIBG) scintigraphy is a widely used functional imaging tool with a high degree of sensitivity and specificity in diagnosis of pheochromocytoma. However, rare cases of false positive reactions have been reported. A 67-year-old male patient was admitted with epigastric pain. Abdominal computed tomography (CT) revealed a heterogeneous left adrenal mass 6 cm in diameter; following hormone testing, 123I-MIBG scintigraphy was performed to determine the presence of pheochromocytoma, which confirmed eccentric uptake by a large left adrenal gland mass. Chest CT and PET-CT confirmed metastatic lymphadenopathy; therefore, endobronchial ultrasound transbronchial needle aspiration was performed. Metastatic carcinoma of unknown origin was suspected from a lymph node biopsy, and surgical resection was performed for definitive diagnosis and correction of excess hormonal secretion. A final diagnosis of undifferentiated adrenal malignant tumor was rendered, instead of histologically malignant pheochromocytoma, despite the uptake of 123I-MIBG demonstrated by scintigraphy. |
| format | Article |
| id | doaj-art-63387905860342e9808bb3c260bcf0dd |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-63387905860342e9808bb3c260bcf0dd2025-02-03T00:59:14ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/164280164280False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant TumorHee Soo Jung0Seok Jun Moon1Yun Mi Kim2Hye Rim Kang3Seok Mo Lee4Soo Jin Jung5Seok Jin Choi6Tae Kyoon Kim7Min Jeong Kwon8Jeong Hyun Park9Soon Hee Lee10Department of Internal Medicine, College of Medicine, Inje University, Busan 614-735, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Inje University, Busan 614-735, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Inje University, Busan 614-735, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Inje University, Busan 614-735, Republic of KoreaDepartment of Nuclear Medicine, Busan Paik Hospital, College of Medicine, Inje University, Busan 614-735, Republic of KoreaDepartment of Pathology, Busan Paik Hospital, College of Medicine, Inje University, Busan 614-735, Republic of KoreaDepartment of Radiology, Busan Paik Hospital, College of Medicine, Inje University, Busan 614-735, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Inje University, Busan 614-735, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Inje University, Busan 614-735, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Inje University, Busan 614-735, Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Inje University, Busan 614-735, Republic of Korea123I-Metaiodobenzylguanidine (123I-MIBG) scintigraphy is a widely used functional imaging tool with a high degree of sensitivity and specificity in diagnosis of pheochromocytoma. However, rare cases of false positive reactions have been reported. A 67-year-old male patient was admitted with epigastric pain. Abdominal computed tomography (CT) revealed a heterogeneous left adrenal mass 6 cm in diameter; following hormone testing, 123I-MIBG scintigraphy was performed to determine the presence of pheochromocytoma, which confirmed eccentric uptake by a large left adrenal gland mass. Chest CT and PET-CT confirmed metastatic lymphadenopathy; therefore, endobronchial ultrasound transbronchial needle aspiration was performed. Metastatic carcinoma of unknown origin was suspected from a lymph node biopsy, and surgical resection was performed for definitive diagnosis and correction of excess hormonal secretion. A final diagnosis of undifferentiated adrenal malignant tumor was rendered, instead of histologically malignant pheochromocytoma, despite the uptake of 123I-MIBG demonstrated by scintigraphy.http://dx.doi.org/10.1155/2015/164280 |
| spellingShingle | Hee Soo Jung Seok Jun Moon Yun Mi Kim Hye Rim Kang Seok Mo Lee Soo Jin Jung Seok Jin Choi Tae Kyoon Kim Min Jeong Kwon Jeong Hyun Park Soon Hee Lee False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor Case Reports in Oncological Medicine |
| title | False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor |
| title_full | False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor |
| title_fullStr | False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor |
| title_full_unstemmed | False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor |
| title_short | False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor |
| title_sort | false positive radioiodinated metaiodobenzylguanidine 123i mibg uptake in undifferentiated adrenal malignant tumor |
| url | http://dx.doi.org/10.1155/2015/164280 |
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