Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis

Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis

Advanced metastatic colorectal cancer (CRC) with deficient DNA mismatch repair (MMR-d), or immune-hot CRCs, show significantly improved clinical outcomes compared to MMR-proficient (MMR-p), or immune-cold CRCs. While the prior represents about 5% of all CRCs, the latter represent 95% and are charact...

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Bibliographic Details
Main Authors: Daciana C. Dumut, Marian Hajduch, Amanda M. Zacharias, Qingling Duan, Ivo Frydrych, Zuzana Rozankova, Miroslav Popper, Dusan Garic, Radu Alexandru Paun, Amanda Centorame, Juhi Shah, Martin Mistrik, Petr Dzubak, Juan B. De Sanctis, Danuta Radzioch
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
copper bis-diethyldithiocarbamate
disulfiram
colorectal cancer
NK cells
NKG2D
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1491450/full
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