Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation. The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2012/136937 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549937593712640 |
|---|---|
| author | Humberto Nicastro Claudia Ribeiro da Luz Daniela Fojo Seixas Chaves Luiz Roberto Grassmann Bechara Vanessa Azevedo Voltarelli Marcelo Macedo Rogero Antonio Herbert Lancha |
| author_facet | Humberto Nicastro Claudia Ribeiro da Luz Daniela Fojo Seixas Chaves Luiz Roberto Grassmann Bechara Vanessa Azevedo Voltarelli Marcelo Macedo Rogero Antonio Herbert Lancha |
| author_sort | Humberto Nicastro |
| collection | DOAJ |
| description | Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation. The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. In this context, branched-chain amino acids (BCAAs), especially leucine, have been described as a strong nutritional stimulus able to enhance protein translation initiation and attenuate proteolysis. Furthermore, under inflammatory conditions, BCAA can be transaminated to glutamate in order to increase glutamine synthesis, which is a substrate highly consumed by inflammatory cells such as macrophages. The present paper describes the role of inflammation on muscle remodeling and the possible metabolic and cellular effects of BCAA supplementation in the modulation of inflammatory status of skeletal muscle and the consequences on protein synthesis and degradation. |
| format | Article |
| id | doaj-art-63371884d5b246b182c43de3ac1e6d38 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-63371884d5b246b182c43de3ac1e6d382025-02-03T06:08:09ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322012-01-01201210.1155/2012/136937136937Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of ActionHumberto Nicastro0Claudia Ribeiro da Luz1Daniela Fojo Seixas Chaves2Luiz Roberto Grassmann Bechara3Vanessa Azevedo Voltarelli4Marcelo Macedo Rogero5Antonio Herbert Lancha6Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030 São Paulo, SP, BrazilLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030 São Paulo, SP, BrazilLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030 São Paulo, SP, BrazilLaboratory of Molecular and Cellular Physiology of Exercise, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030, São Paulo, SP, BrazilLaboratory of Molecular and Cellular Physiology of Exercise, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030, São Paulo, SP, BrazilDepartment of Nutrition, School of Public Health, University of São Paulo, P.O. Box 01246-904, São Paulo, SP, BrazilLaboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030 São Paulo, SP, BrazilSkeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation. The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. In this context, branched-chain amino acids (BCAAs), especially leucine, have been described as a strong nutritional stimulus able to enhance protein translation initiation and attenuate proteolysis. Furthermore, under inflammatory conditions, BCAA can be transaminated to glutamate in order to increase glutamine synthesis, which is a substrate highly consumed by inflammatory cells such as macrophages. The present paper describes the role of inflammation on muscle remodeling and the possible metabolic and cellular effects of BCAA supplementation in the modulation of inflammatory status of skeletal muscle and the consequences on protein synthesis and degradation.http://dx.doi.org/10.1155/2012/136937 |
| spellingShingle | Humberto Nicastro Claudia Ribeiro da Luz Daniela Fojo Seixas Chaves Luiz Roberto Grassmann Bechara Vanessa Azevedo Voltarelli Marcelo Macedo Rogero Antonio Herbert Lancha Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action Journal of Nutrition and Metabolism |
| title | Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action |
| title_full | Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action |
| title_fullStr | Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action |
| title_full_unstemmed | Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action |
| title_short | Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action |
| title_sort | does branched chain amino acids supplementation modulate skeletal muscle remodeling through inflammation modulation possible mechanisms of action |
| url | http://dx.doi.org/10.1155/2012/136937 |
| work_keys_str_mv | AT humbertonicastro doesbranchedchainaminoacidssupplementationmodulateskeletalmuscleremodelingthroughinflammationmodulationpossiblemechanismsofaction AT claudiaribeirodaluz doesbranchedchainaminoacidssupplementationmodulateskeletalmuscleremodelingthroughinflammationmodulationpossiblemechanismsofaction AT danielafojoseixaschaves doesbranchedchainaminoacidssupplementationmodulateskeletalmuscleremodelingthroughinflammationmodulationpossiblemechanismsofaction AT luizrobertograssmannbechara doesbranchedchainaminoacidssupplementationmodulateskeletalmuscleremodelingthroughinflammationmodulationpossiblemechanismsofaction AT vanessaazevedovoltarelli doesbranchedchainaminoacidssupplementationmodulateskeletalmuscleremodelingthroughinflammationmodulationpossiblemechanismsofaction AT marcelomacedorogero doesbranchedchainaminoacidssupplementationmodulateskeletalmuscleremodelingthroughinflammationmodulationpossiblemechanismsofaction AT antonioherbertlancha doesbranchedchainaminoacidssupplementationmodulateskeletalmuscleremodelingthroughinflammationmodulationpossiblemechanismsofaction |