CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. In recent years, circular RNAs (circRNAs), a novel class of non-coding RNA molecules, have emerged as a research focus due to their unique stability and functional roles. CircRNAs regulate tumor-related signa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1525779/full |
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| author | Jingjing Yang Jingjing Yang Qiqi Fan Yiyun Wang Yuanyue Liu Xiaoning Xu Yeqi Liang Jiakang Xie Jiajie Li Fengting Ai Yong Cao Shangzhen Yu Jinman Liu |
| author_facet | Jingjing Yang Jingjing Yang Qiqi Fan Yiyun Wang Yuanyue Liu Xiaoning Xu Yeqi Liang Jiakang Xie Jiajie Li Fengting Ai Yong Cao Shangzhen Yu Jinman Liu |
| author_sort | Jingjing Yang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. In recent years, circular RNAs (circRNAs), a novel class of non-coding RNA molecules, have emerged as a research focus due to their unique stability and functional roles. CircRNAs regulate tumor-related signaling pathways through interactions with microRNAs (miRNAs) and proteins, playing key roles in tumorigenesis, progression, invasion, metastasis, and chemoresistance. This review summarizes the role of circRNAs in CRC, particularly their mechanisms in cell proliferation, migration, apoptosis, tumor microenvironment (TME) remodeling, and immune evasion. Aberrant expression of circRNAs holds great potential as diagnostic and prognostic biomarkers as well as therapeutic targets for CRC. Additionally, natural products such as flavonoids and glycosides, by modulating circRNA-miRNA-mRNA networks, offer promising therapeutic strategies. The article also discusses the current technical challenges in circRNA research and its future application prospects in CRC, highlighting the need for further investigation into the role of circRNAs in tumor immune microenvironments and drug resistance mechanisms. |
| format | Article |
| id | doaj-art-632d36e76e6a4a54ba9bf84f1ecc87b5 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-632d36e76e6a4a54ba9bf84f1ecc87b52025-01-29T06:45:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.15257791525779CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulationJingjing Yang0Jingjing Yang1Qiqi Fan2Yiyun Wang3Yuanyue Liu4Xiaoning Xu5Yeqi Liang6Jiakang Xie7Jiajie Li8Fengting Ai9Yong Cao10Shangzhen Yu11Jinman Liu12Central Laboratory, Affiliated Jiangmen Traditional Chinese Medicine (TCM) Hospital of Ji’nan University, Jiangmen, ChinaDepartment of Oncology, Huangpu People’s Hospital of Zhongshan, Zhongshan, ChinaCentral Laboratory, Affiliated Jiangmen Traditional Chinese Medicine (TCM) Hospital of Ji’nan University, Jiangmen, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Traditional Chinese Medicine, Ji’nan University, Guangzhou, ChinaSchool of Traditional Chinese Medicine, Ji’nan University, Guangzhou, ChinaSchool of Traditional Chinese Medicine, Ji’nan University, Guangzhou, ChinaSchool of Traditional Chinese Medicine, Ji’nan University, Guangzhou, ChinaSchool of Traditional Chinese Medicine, Ji’nan University, Guangzhou, ChinaSchool of Traditional Chinese Medicine, Ji’nan University, Guangzhou, ChinaCentral Laboratory, Affiliated Jiangmen Traditional Chinese Medicine (TCM) Hospital of Ji’nan University, Jiangmen, ChinaCentral Laboratory, Affiliated Jiangmen Traditional Chinese Medicine (TCM) Hospital of Ji’nan University, Jiangmen, ChinaColorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. In recent years, circular RNAs (circRNAs), a novel class of non-coding RNA molecules, have emerged as a research focus due to their unique stability and functional roles. CircRNAs regulate tumor-related signaling pathways through interactions with microRNAs (miRNAs) and proteins, playing key roles in tumorigenesis, progression, invasion, metastasis, and chemoresistance. This review summarizes the role of circRNAs in CRC, particularly their mechanisms in cell proliferation, migration, apoptosis, tumor microenvironment (TME) remodeling, and immune evasion. Aberrant expression of circRNAs holds great potential as diagnostic and prognostic biomarkers as well as therapeutic targets for CRC. Additionally, natural products such as flavonoids and glycosides, by modulating circRNA-miRNA-mRNA networks, offer promising therapeutic strategies. The article also discusses the current technical challenges in circRNA research and its future application prospects in CRC, highlighting the need for further investigation into the role of circRNAs in tumor immune microenvironments and drug resistance mechanisms.https://www.frontiersin.org/articles/10.3389/fonc.2025.1525779/fullcolorectal cancer (CRC)circular RNAs (circRNAs)biological functionprognostic biomarkerspotential therapeutic biomarkersnatural product-based regulation |
| spellingShingle | Jingjing Yang Jingjing Yang Qiqi Fan Yiyun Wang Yuanyue Liu Xiaoning Xu Yeqi Liang Jiakang Xie Jiajie Li Fengting Ai Yong Cao Shangzhen Yu Jinman Liu CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation Frontiers in Oncology colorectal cancer (CRC) circular RNAs (circRNAs) biological function prognostic biomarkers potential therapeutic biomarkers natural product-based regulation |
| title | CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation |
| title_full | CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation |
| title_fullStr | CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation |
| title_full_unstemmed | CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation |
| title_short | CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation |
| title_sort | circrnas in colorectal cancer potential roles clinical applications and natural product based regulation |
| topic | colorectal cancer (CRC) circular RNAs (circRNAs) biological function prognostic biomarkers potential therapeutic biomarkers natural product-based regulation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1525779/full |
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