Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease
Genetic retinal diseases such as age-related macular degeneration and monogenic diseases such as retinitis pigmentosa account for some of the commonest causes of blindness in the developed world. Diverse genetic abnormalities and environmental causes have been implicated in triggering multiple patho...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/581751 |
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| author | Ishaq A. Viringipurampeer Abu E. Bashar Cheryl Y. Gregory-Evans Orson L. Moritz Kevin Gregory-Evans |
| author_facet | Ishaq A. Viringipurampeer Abu E. Bashar Cheryl Y. Gregory-Evans Orson L. Moritz Kevin Gregory-Evans |
| author_sort | Ishaq A. Viringipurampeer |
| collection | DOAJ |
| description | Genetic retinal diseases such as age-related macular degeneration and monogenic diseases such as retinitis pigmentosa account for some of the commonest causes of blindness in the developed world. Diverse genetic abnormalities and environmental causes have been implicated in triggering multiple pathological mechanisms such as oxidative stress, lipofuscin deposits, neovascularisation, and programmed cell death. In recent years, inflammation has also been highlighted although whether inflammatory mediators play a central role in pathogenesis or a more minor secondary role has yet to be established. Despite this, numerous interventional studies, particularly targeting the complement system, are underway with the promise of novel therapeutic strategies for these important blinding conditions. |
| format | Article |
| id | doaj-art-630b48aac0fc4fc4872ae94b933bfc6a |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-630b48aac0fc4fc4872ae94b933bfc6a2025-02-03T06:07:17ZengWileyInternational Journal of Inflammation2090-80402042-00992013-01-01201310.1155/2013/581751581751Targeting Inflammation in Emerging Therapies for Genetic Retinal DiseaseIshaq A. Viringipurampeer0Abu E. Bashar1Cheryl Y. Gregory-Evans2Orson L. Moritz3Kevin Gregory-Evans4Eye Care Centre, Department of Ophthalmology and Visual Science, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, CanadaEye Care Centre, Department of Ophthalmology and Visual Science, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, CanadaEye Care Centre, Department of Ophthalmology and Visual Science, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, CanadaEye Care Centre, Department of Ophthalmology and Visual Science, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, CanadaEye Care Centre, Department of Ophthalmology and Visual Science, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, CanadaGenetic retinal diseases such as age-related macular degeneration and monogenic diseases such as retinitis pigmentosa account for some of the commonest causes of blindness in the developed world. Diverse genetic abnormalities and environmental causes have been implicated in triggering multiple pathological mechanisms such as oxidative stress, lipofuscin deposits, neovascularisation, and programmed cell death. In recent years, inflammation has also been highlighted although whether inflammatory mediators play a central role in pathogenesis or a more minor secondary role has yet to be established. Despite this, numerous interventional studies, particularly targeting the complement system, are underway with the promise of novel therapeutic strategies for these important blinding conditions.http://dx.doi.org/10.1155/2013/581751 |
| spellingShingle | Ishaq A. Viringipurampeer Abu E. Bashar Cheryl Y. Gregory-Evans Orson L. Moritz Kevin Gregory-Evans Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease International Journal of Inflammation |
| title | Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease |
| title_full | Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease |
| title_fullStr | Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease |
| title_full_unstemmed | Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease |
| title_short | Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease |
| title_sort | targeting inflammation in emerging therapies for genetic retinal disease |
| url | http://dx.doi.org/10.1155/2013/581751 |
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