Tea consumption and incidence of type 2 diabetes in Europe: the EPIC-InterAct case-cohort study.

Tea consumption and incidence of type 2 diabetes in Europe: the EPIC-InterAct case-cohort study.

<h4>Background</h4>In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incide...

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Main Authors: InterAct Consortium, Geertruida J van Woudenbergh, Anneleen Kuijsten, Dagmar Drogan, Daphne L van der A, Dora Romaguera, Eva Ardanaz, Pilar Amiano, Aurelio Barricarte, Joline W J Beulens, Heiner Boeing, H Bas Bueno-de-Mesquita, Christina C Dahm, M-Doleres Chirlaque, Francoise Clavel, Francesca L Crowe, Piia-Piret Eomois, Guy Fagherazzi, Paul W Franks, Jytte Halkjaer, Kay T Khaw, Giovanna Masala, Amalia Mattiello, Peter Nilsson, Kim Overvad, J Ramón Quirós, Olov Rolandsson, Isabelle Romieu, Carlotta Sacerdote, María-José Sánchez, Matthias B Schulze, Nadia Slimani, Ivonne Sluijs, Annemieke M W Spijkerman, Giovanna Tagliabue, Anne Tjønneland, Rosario Tumino, Nita G Forouhi, Stephen Sharp, Claudia Langenberg, Edith J M Feskens, Elio Riboli, Nicholas J Wareham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0036910&type=printable
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Summary:<h4>Background</h4>In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population.<h4>Methodology/principal findings</h4>The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-<1, 1-<4, ≥ 4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95%CI 0.71, 1.00] when participants who drank ≥ 4 cups of tea per day were compared with non-drinkers (p(linear trend) = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-<4 cups/day (HR = 0.93 [95%CI 0.81, 1.05]). Spline regression did not suggest a non-linear association (p(non-linearity) = 0.20).<h4>Conclusions/significance</h4>A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.
ISSN:1932-6203

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