Synthesis and Antibacterial Activity of Some New Phenothiazine Derivatives
A series of some new phenothiazine derivatives were synthesized with the objective for evaluation as antimicrobials. The title compounds were prepared by a five step synthesis scheme. 2-Amino-6-substituted benzothiazoles (1) on diazotization afford 6-substituted benzothiazolyl-2-diazonium chlorides...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2007/402673 |
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| author | Pawan Kumar Swarnkar P. Kriplani G. N. Gupta K. G. Ojha |
| author_facet | Pawan Kumar Swarnkar P. Kriplani G. N. Gupta K. G. Ojha |
| author_sort | Pawan Kumar Swarnkar |
| collection | DOAJ |
| description | A series of some new phenothiazine derivatives were synthesized with the objective for evaluation as antimicrobials. The title compounds were prepared by a five step synthesis scheme. 2-Amino-6-substituted benzothiazoles (1) on diazotization afford 6-substituted benzothiazolyl-2-diazonium chlorides (2). Reaction of 2 with cold solution of β-naphthol in dilute NaOH furnishes α-(2-diazo-6-substituted benzothiazolyl)- β-sodionaphthoxides (3) which on acidification with concentrated HCl gives α-(2-diazo-6-substituted benzothiazolyl)-β-naphthols (4). Reaction of 4 with p-substituted anilines gives α-(2-diazo-6-substituted benzothiazolyl)-β-(p-substituted anilino) naphthalenes (5). This synthesis besides by using conventional methods was also attempted using microwave. Fusion of 5 with sulphur in presence of iodine results in α-(2-diazo-6-substituted benzothiazolyl)-6- substituted [2, 3-b] benzophenothiazines(6). The structures of all these compounds have been supported by elemental analysis and their spectral studies. All synthesized compounds were tested for their antibacterial activity using standard drugs. |
| format | Article |
| id | doaj-art-62e7c7d4b6744232bcf98870ca227dcc |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-62e7c7d4b6744232bcf98870ca227dcc2025-02-03T01:22:10ZengWileyE-Journal of Chemistry0973-49452090-98102007-01-0141142010.1155/2007/402673Synthesis and Antibacterial Activity of Some New Phenothiazine DerivativesPawan Kumar Swarnkar0P. Kriplani1G. N. Gupta2K. G. Ojha3Department of Pure and Applied Chemistry, Maharshi Dayanand Saraswati University, Ajmer, Rajasthan, 305009, IndiaDepartment of Pure and Applied Chemistry, Maharshi Dayanand Saraswati University, Ajmer, Rajasthan, 305009, IndiaDepartment of Pure and Applied Chemistry, Maharshi Dayanand Saraswati University, Ajmer, Rajasthan, 305009, IndiaDepartment of Pure and Applied Chemistry, Maharshi Dayanand Saraswati University, Ajmer, Rajasthan, 305009, IndiaA series of some new phenothiazine derivatives were synthesized with the objective for evaluation as antimicrobials. The title compounds were prepared by a five step synthesis scheme. 2-Amino-6-substituted benzothiazoles (1) on diazotization afford 6-substituted benzothiazolyl-2-diazonium chlorides (2). Reaction of 2 with cold solution of β-naphthol in dilute NaOH furnishes α-(2-diazo-6-substituted benzothiazolyl)- β-sodionaphthoxides (3) which on acidification with concentrated HCl gives α-(2-diazo-6-substituted benzothiazolyl)-β-naphthols (4). Reaction of 4 with p-substituted anilines gives α-(2-diazo-6-substituted benzothiazolyl)-β-(p-substituted anilino) naphthalenes (5). This synthesis besides by using conventional methods was also attempted using microwave. Fusion of 5 with sulphur in presence of iodine results in α-(2-diazo-6-substituted benzothiazolyl)-6- substituted [2, 3-b] benzophenothiazines(6). The structures of all these compounds have been supported by elemental analysis and their spectral studies. All synthesized compounds were tested for their antibacterial activity using standard drugs.http://dx.doi.org/10.1155/2007/402673 |
| spellingShingle | Pawan Kumar Swarnkar P. Kriplani G. N. Gupta K. G. Ojha Synthesis and Antibacterial Activity of Some New Phenothiazine Derivatives E-Journal of Chemistry |
| title | Synthesis and Antibacterial Activity of Some New Phenothiazine Derivatives |
| title_full | Synthesis and Antibacterial Activity of Some New Phenothiazine Derivatives |
| title_fullStr | Synthesis and Antibacterial Activity of Some New Phenothiazine Derivatives |
| title_full_unstemmed | Synthesis and Antibacterial Activity of Some New Phenothiazine Derivatives |
| title_short | Synthesis and Antibacterial Activity of Some New Phenothiazine Derivatives |
| title_sort | synthesis and antibacterial activity of some new phenothiazine derivatives |
| url | http://dx.doi.org/10.1155/2007/402673 |
| work_keys_str_mv | AT pawankumarswarnkar synthesisandantibacterialactivityofsomenewphenothiazinederivatives AT pkriplani synthesisandantibacterialactivityofsomenewphenothiazinederivatives AT gngupta synthesisandantibacterialactivityofsomenewphenothiazinederivatives AT kgojha synthesisandantibacterialactivityofsomenewphenothiazinederivatives |