Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of Tanzania
The syndromic diagnosis of sexually transmitted infections (STIs) is widely recognized as the most practical, feasible, and cost-effective diagnostic tool in resource-limited settings. This study assessed the diagnostic accuracy of syndromic versus laboratory testing of STIs among 794 men randomly s...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2020/7607834 |
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| author | Yuwei Cheng Elijah Paintsil Musie Ghebremichael |
| author_facet | Yuwei Cheng Elijah Paintsil Musie Ghebremichael |
| author_sort | Yuwei Cheng |
| collection | DOAJ |
| description | The syndromic diagnosis of sexually transmitted infections (STIs) is widely recognized as the most practical, feasible, and cost-effective diagnostic tool in resource-limited settings. This study assessed the diagnostic accuracy of syndromic versus laboratory testing of STIs among 794 men randomly selected from the Moshi district of Tanzania. Participants were interviewed with a questionnaire that included questions on history of STIs symptoms. Blood and urine samples were taken from the participants for laboratory testing. Only 7.9% of the men reported any symptoms of STI; however, 46% of them tested positive for at least one STI. There was little agreement between syndromic and laboratory-confirmed diagnoses, with low sensitivity (0.4%–7.4%) and high specificity (96%–100%) observed for each individual symptom. The area under the receiver-operating curve was 0.528 (95% CI: 0.505–0.550), indicating that the syndromic approach has a 52.8% probability of correctly identifying STIs in study participants. In conclusion, whenever possible, laboratory diagnosis of STI should be favored over syndromic diagnosis. |
| format | Article |
| id | doaj-art-62ca306a47ec452db34221c4d24ac875 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-62ca306a47ec452db34221c4d24ac8752025-02-03T06:05:13ZengWileyAIDS Research and Treatment2090-12402090-12592020-01-01202010.1155/2020/76078347607834Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of TanzaniaYuwei Cheng0Elijah Paintsil1Musie Ghebremichael2Department of Mathematical and Computer Sciences, College of the Holy Cross, Worcester, MA, USADepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USAHarvard Medical School, Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USAThe syndromic diagnosis of sexually transmitted infections (STIs) is widely recognized as the most practical, feasible, and cost-effective diagnostic tool in resource-limited settings. This study assessed the diagnostic accuracy of syndromic versus laboratory testing of STIs among 794 men randomly selected from the Moshi district of Tanzania. Participants were interviewed with a questionnaire that included questions on history of STIs symptoms. Blood and urine samples were taken from the participants for laboratory testing. Only 7.9% of the men reported any symptoms of STI; however, 46% of them tested positive for at least one STI. There was little agreement between syndromic and laboratory-confirmed diagnoses, with low sensitivity (0.4%–7.4%) and high specificity (96%–100%) observed for each individual symptom. The area under the receiver-operating curve was 0.528 (95% CI: 0.505–0.550), indicating that the syndromic approach has a 52.8% probability of correctly identifying STIs in study participants. In conclusion, whenever possible, laboratory diagnosis of STI should be favored over syndromic diagnosis.http://dx.doi.org/10.1155/2020/7607834 |
| spellingShingle | Yuwei Cheng Elijah Paintsil Musie Ghebremichael Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of Tanzania AIDS Research and Treatment |
| title | Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of Tanzania |
| title_full | Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of Tanzania |
| title_fullStr | Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of Tanzania |
| title_full_unstemmed | Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of Tanzania |
| title_short | Syndromic versus Laboratory Diagnosis of Sexually Transmitted Infections in Men in Moshi District of Tanzania |
| title_sort | syndromic versus laboratory diagnosis of sexually transmitted infections in men in moshi district of tanzania |
| url | http://dx.doi.org/10.1155/2020/7607834 |
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