Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in mice
It is well known that exposure to environmental stresses could enhance the adaptability of bacteria and up-regulate the expression of a variety of oxidative stress-related genes and antioxidant enzymes. It is unclear whether the adaptability of microorganisms formed naturally in special environments...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000544 |
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| author | Sisi Chen Shimin Jia Keke Suo Qiaozhen Kang Limin Hao Laizheng Lu Xin Liu Jinyong Huang Jike Lu |
| author_facet | Sisi Chen Shimin Jia Keke Suo Qiaozhen Kang Limin Hao Laizheng Lu Xin Liu Jinyong Huang Jike Lu |
| author_sort | Sisi Chen |
| collection | DOAJ |
| description | It is well known that exposure to environmental stresses could enhance the adaptability of bacteria and up-regulate the expression of a variety of oxidative stress-related genes and antioxidant enzymes. It is unclear whether the adaptability of microorganisms formed naturally in special environments could transfer to other organisms. The study aimed to evaluate the effects of untreated and ethanol-induced Lactococcus lactis intracellular extracts (U-IE and E-IE) on alcohol metabolism in mice. The positive effects of E-IE on alcohol metabolism in mice were revealed by the enhanced latency of loss of righting reflex (LORR), the reduced duration of LORR, the decrease of blood alcohol concentration, as well as the elevation of alcohol dehydrogenase (ADH) activities in the stomach and liver tissues. Furthermore, the potential benefits of E-IE on the liver were evaluated by biochemical parameters including the activities of serum transaminase, the levels of antioxidant enzymes, and the pathological changes of liver tissue. The present work put forward a new point that appropriate ethanol stress could enhance the intracellular ADH activity of L. lactis, and its intracellular extracts could continue to enhance alcohol metabolism in mice. |
| format | Article |
| id | doaj-art-62c9cdda94764094ac153e3081a9242c |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-62c9cdda94764094ac153e3081a9242c2025-02-03T06:15:29ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111511831190Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in miceSisi Chen0Shimin Jia1Keke Suo2Qiaozhen Kang3Limin Hao4Laizheng Lu5Xin Liu6Jinyong Huang7Jike Lu8School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China; Physical Education College, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaThe Quartermaster Research Institute of Engineering and Technology, Academy of Military Sciences PLA China, Beijing 100010, ChinaZhengzhou Mindtek Biotechnology Co., Ltd., Zhengzhou 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Agricultural Sciences, Zhengzhou University 450001, ChinaSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, China; Corresponding authors. Fax: 86-371-67783235It is well known that exposure to environmental stresses could enhance the adaptability of bacteria and up-regulate the expression of a variety of oxidative stress-related genes and antioxidant enzymes. It is unclear whether the adaptability of microorganisms formed naturally in special environments could transfer to other organisms. The study aimed to evaluate the effects of untreated and ethanol-induced Lactococcus lactis intracellular extracts (U-IE and E-IE) on alcohol metabolism in mice. The positive effects of E-IE on alcohol metabolism in mice were revealed by the enhanced latency of loss of righting reflex (LORR), the reduced duration of LORR, the decrease of blood alcohol concentration, as well as the elevation of alcohol dehydrogenase (ADH) activities in the stomach and liver tissues. Furthermore, the potential benefits of E-IE on the liver were evaluated by biochemical parameters including the activities of serum transaminase, the levels of antioxidant enzymes, and the pathological changes of liver tissue. The present work put forward a new point that appropriate ethanol stress could enhance the intracellular ADH activity of L. lactis, and its intracellular extracts could continue to enhance alcohol metabolism in mice.http://www.sciencedirect.com/science/article/pii/S2213453022000544Ethanol stressIntracellular extractsAlcohol dehydrogenaseAlcohol metabolism |
| spellingShingle | Sisi Chen Shimin Jia Keke Suo Qiaozhen Kang Limin Hao Laizheng Lu Xin Liu Jinyong Huang Jike Lu Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in mice Food Science and Human Wellness Ethanol stress Intracellular extracts Alcohol dehydrogenase Alcohol metabolism |
| title | Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in mice |
| title_full | Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in mice |
| title_fullStr | Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in mice |
| title_full_unstemmed | Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in mice |
| title_short | Positive effect of ethanol-induced Lactococcus lactis on alcohol metabolism in mice |
| title_sort | positive effect of ethanol induced lactococcus lactis on alcohol metabolism in mice |
| topic | Ethanol stress Intracellular extracts Alcohol dehydrogenase Alcohol metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000544 |
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