The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women
The Trp719Arg allele of KIF6 rs20455, a putative risk factor for CHD especially in those with elevated low-density lipoprotein cholesterol (LDL-C), was investigated in Filipino-American women (FAW, n=235) participating in health screenings in four cities. The rs20455 genotype of each subject was d...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Nursing Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/328954 |
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| author | Irma B. Ancheta Cynthia A. Battie Dan Richard Christine V. Ancheta Nancy Borja-Hart Annabelle S. Volgman Yvette Conley |
| author_facet | Irma B. Ancheta Cynthia A. Battie Dan Richard Christine V. Ancheta Nancy Borja-Hart Annabelle S. Volgman Yvette Conley |
| author_sort | Irma B. Ancheta |
| collection | DOAJ |
| description | The Trp719Arg allele of KIF6 rs20455, a putative risk factor for CHD especially in those with elevated low-density lipoprotein cholesterol (LDL-C), was investigated in Filipino-American women (FAW, n=235) participating in health screenings in four cities. The rs20455 genotype of each subject was determined by a multiplex assay using a Luminex-OLA procedure. The risk allele Trp719Arg was present in 77% of the subjects. The genotype distribution was 23% Trp/Trp, 51% Arg/Trp, and 26% Arg/Arg. Genotype did not predict the presence of CHD risk factors. Moreover, LDL-C, HDL-C, and triglycerides mean values did not vary as a function of genotype. However, those with the Arg/Arg genotype on statin medication exhibited a significantly higher mean triglycerides level (P<0.01). Approximately 60% of participants regardless of genotype exhibited LDL-C levels ≥100 mg/dL but were not taking medication. Approximately 43% of those with the Trp719Arg risk allele on statins exhibited elevated LDL-C levels. Our study suggests that the Trp719Arg allele of KIF 6 rs20455 is common among Filipino-American women; thus, even with borderline LDL-C levels would benefit from statin treatment. Secondly, many participants did not exhibit guideline recommended LDL-C levels including many who were on statin drugs. |
| format | Article |
| id | doaj-art-62c34a9ddccd46bea23124b3dcc0b1c8 |
| institution | Kabale University |
| issn | 2090-1429 2090-1437 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Nursing Research and Practice |
| spelling | doaj-art-62c34a9ddccd46bea23124b3dcc0b1c82025-02-03T01:21:25ZengWileyNursing Research and Practice2090-14292090-14372014-01-01201410.1155/2014/328954328954The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American WomenIrma B. Ancheta0Cynthia A. Battie1Dan Richard2Christine V. Ancheta3Nancy Borja-Hart4Annabelle S. Volgman5Yvette Conley6School of Nursing, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USASchool of Nursing, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USASchool of Nursing, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USAUniversity of South Florida, Tampa, FL 33612, USAEast Coast Institute for Research, Jacksonville, FL 32223, USARush University Medical Center, Chicago, IL 60612, USAUniversity Pittsburgh, Pittsburgh, PA 15213, USAThe Trp719Arg allele of KIF6 rs20455, a putative risk factor for CHD especially in those with elevated low-density lipoprotein cholesterol (LDL-C), was investigated in Filipino-American women (FAW, n=235) participating in health screenings in four cities. The rs20455 genotype of each subject was determined by a multiplex assay using a Luminex-OLA procedure. The risk allele Trp719Arg was present in 77% of the subjects. The genotype distribution was 23% Trp/Trp, 51% Arg/Trp, and 26% Arg/Arg. Genotype did not predict the presence of CHD risk factors. Moreover, LDL-C, HDL-C, and triglycerides mean values did not vary as a function of genotype. However, those with the Arg/Arg genotype on statin medication exhibited a significantly higher mean triglycerides level (P<0.01). Approximately 60% of participants regardless of genotype exhibited LDL-C levels ≥100 mg/dL but were not taking medication. Approximately 43% of those with the Trp719Arg risk allele on statins exhibited elevated LDL-C levels. Our study suggests that the Trp719Arg allele of KIF 6 rs20455 is common among Filipino-American women; thus, even with borderline LDL-C levels would benefit from statin treatment. Secondly, many participants did not exhibit guideline recommended LDL-C levels including many who were on statin drugs.http://dx.doi.org/10.1155/2014/328954 |
| spellingShingle | Irma B. Ancheta Cynthia A. Battie Dan Richard Christine V. Ancheta Nancy Borja-Hart Annabelle S. Volgman Yvette Conley The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women Nursing Research and Practice |
| title | The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women |
| title_full | The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women |
| title_fullStr | The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women |
| title_full_unstemmed | The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women |
| title_short | The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women |
| title_sort | association between kif6 single nucleotide polymorphism rs20455 and serum lipids in filipino american women |
| url | http://dx.doi.org/10.1155/2014/328954 |
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