Undifferentiated carcinoma of the uterine cervix with evidence of its origin from small-cell neuroendocrine carcinoma
Neuroendocrine carcinoma (NEC) of the uterine cervix is an uncommon aggressive tumor, comprises <5% of the cervical malignancies. Undifferentiated carcinoma of the cervix, described by the World Health Organization Classification of Tumors as a distinct entity, is extremely rare with no histologi...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2018-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=4;spage=536;epage=538;aulast=Muthusamy |
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| _version_ | 1849315522488827904 |
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| author | Rajeshwari K Muthusamy Sangita S Mehta |
| author_facet | Rajeshwari K Muthusamy Sangita S Mehta |
| author_sort | Rajeshwari K Muthusamy |
| collection | DOAJ |
| description | Neuroendocrine carcinoma (NEC) of the uterine cervix is an uncommon aggressive tumor, comprises <5% of the cervical malignancies. Undifferentiated carcinoma of the cervix, described by the World Health Organization Classification of Tumors as a distinct entity, is extremely rare with no histologic evidence of differentiation. Immunohistochemistry with p63 and neuroendocrine markers helps in delineating the type as undifferentiated squamous cell carcinoma or NEC. NEC of the uterine cervix behaves biologically like any other cervical malignancy, has an association with human papillomavirus, and is similar to NEC of any possible site with early metastasis and poorer survival. We present a case of 45-year-old premenopausal female with undifferentiated carcinoma of the uterine cervix originating from small-cell NEC proven by the presence of differentiated component in the proximity of undifferentiated tumor and by the immunohistochemistry. |
| format | Article |
| id | doaj-art-62bdbcc7a7e344789e28ce9ddbca4d7f |
| institution | Kabale University |
| issn | 0971-5851 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-62bdbcc7a7e344789e28ce9ddbca4d7f2025-08-20T03:52:07ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512018-01-0139453653810.4103/ijmpo.ijmpo_23_17Undifferentiated carcinoma of the uterine cervix with evidence of its origin from small-cell neuroendocrine carcinomaRajeshwari K MuthusamySangita S MehtaNeuroendocrine carcinoma (NEC) of the uterine cervix is an uncommon aggressive tumor, comprises <5% of the cervical malignancies. Undifferentiated carcinoma of the cervix, described by the World Health Organization Classification of Tumors as a distinct entity, is extremely rare with no histologic evidence of differentiation. Immunohistochemistry with p63 and neuroendocrine markers helps in delineating the type as undifferentiated squamous cell carcinoma or NEC. NEC of the uterine cervix behaves biologically like any other cervical malignancy, has an association with human papillomavirus, and is similar to NEC of any possible site with early metastasis and poorer survival. We present a case of 45-year-old premenopausal female with undifferentiated carcinoma of the uterine cervix originating from small-cell NEC proven by the presence of differentiated component in the proximity of undifferentiated tumor and by the immunohistochemistry.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=4;spage=536;epage=538;aulast=MuthusamyHuman papillomavirusneuroendocrine carcinomaundifferentiated carcinomauterine cervix |
| spellingShingle | Rajeshwari K Muthusamy Sangita S Mehta Undifferentiated carcinoma of the uterine cervix with evidence of its origin from small-cell neuroendocrine carcinoma Indian Journal of Medical and Paediatric Oncology Human papillomavirus neuroendocrine carcinoma undifferentiated carcinoma uterine cervix |
| title | Undifferentiated carcinoma of the uterine cervix with evidence of its origin from small-cell neuroendocrine carcinoma |
| title_full | Undifferentiated carcinoma of the uterine cervix with evidence of its origin from small-cell neuroendocrine carcinoma |
| title_fullStr | Undifferentiated carcinoma of the uterine cervix with evidence of its origin from small-cell neuroendocrine carcinoma |
| title_full_unstemmed | Undifferentiated carcinoma of the uterine cervix with evidence of its origin from small-cell neuroendocrine carcinoma |
| title_short | Undifferentiated carcinoma of the uterine cervix with evidence of its origin from small-cell neuroendocrine carcinoma |
| title_sort | undifferentiated carcinoma of the uterine cervix with evidence of its origin from small cell neuroendocrine carcinoma |
| topic | Human papillomavirus neuroendocrine carcinoma undifferentiated carcinoma uterine cervix |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=4;spage=536;epage=538;aulast=Muthusamy |
| work_keys_str_mv | AT rajeshwarikmuthusamy undifferentiatedcarcinomaoftheuterinecervixwithevidenceofitsoriginfromsmallcellneuroendocrinecarcinoma AT sangitasmehta undifferentiatedcarcinomaoftheuterinecervixwithevidenceofitsoriginfromsmallcellneuroendocrinecarcinoma |