Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote esophageal squamous cell carcinoma migration and invasion

Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote esophageal squamous cell carcinoma migration and invasion

Abstract Esophageal squamous cell carcinoma (ESCC) is characterized by a complex tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) play a crucial role in the TME that facilitate tumor progression via interactions with cancer cells. However, the mechanisms underlying the activation o...

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Bibliographic Details
Main Authors: Guan’en Qiao, Changjuan Li, Meng Wang, Wenjuan Zhang, Junjie Shi, Bing Meng, Lixia Zhang, Ruiqing Zhang, Huihui Qi, Shuanli Xin
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Gastroenterology
Subjects:
Esophageal squamous cell carcinoma
Hypoxia
Exosome
Cancer-associated fibroblast
CircNRIP1
Online Access:https://doi.org/10.1186/s12876-025-03978-w
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