The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies
This prospective longitudinal study aimed at comparing maternal immune response among naturally conceived (NC; n=25), in vitro fertilization (IVF; n=25), and egg donation (ED; n=25) pregnancies. The main outcome measures were, firstly, to follow up plasma levels of interleukin (IL) 1beta, IL2, IL4,...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/128616 |
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| author | Alicia Martínez-Varea Begoña Pellicer Vicente Serra David Hervás-Marín Alicia Martínez-Romero José Bellver Alfredo Perales-Marín Antonio Pellicer |
| author_facet | Alicia Martínez-Varea Begoña Pellicer Vicente Serra David Hervás-Marín Alicia Martínez-Romero José Bellver Alfredo Perales-Marín Antonio Pellicer |
| author_sort | Alicia Martínez-Varea |
| collection | DOAJ |
| description | This prospective longitudinal study aimed at comparing maternal immune response among naturally conceived (NC; n=25), in vitro fertilization (IVF; n=25), and egg donation (ED; n=25) pregnancies. The main outcome measures were, firstly, to follow up plasma levels of interleukin (IL) 1beta, IL2, IL4, IL5, IL6, IL8, IL10, IL17, interferon gamma, tumor necrosis factor-alpha (TNFα), transforming growth factor-beta (TGFβ), regulated upon activation normal T-cell expressed and secreted (RANTES), stromal cell-derived factor 1 alpha (SDF1α), and decidual granulocyte-macrophage colony-stimulating factor (GM-CSF) during the three trimesters of pregnancy during the three trimesters of pregnancy; secondly, to evaluate if the cytokine and chemokine pattern of ED pregnant women differs from that of those with autologous oocytes and, thirdly, to assess if women with preeclampsia show different cytokine and chemokine profile throughout pregnancy versus women with uneventful pregnancies. Pregnant women in the three study groups displayed similar cytokine and chemokine pattern throughout pregnancy. The levels of all quantified cytokines and chemokines, except RANTES, TNFα, IL8, TGFβ, and SDF1α, rose in the second trimester compared with the first, and these higher values remained in the third trimester. ED pregnancies showed lower SDF1α levels in the third trimester compared with NC and IVF pregnancies. Patients who developed preeclampsia displayed higher SDF1α plasma levels in the third trimester. |
| format | Article |
| id | doaj-art-62a2b24debec4b4fb3b510aed567ee74 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-62a2b24debec4b4fb3b510aed567ee742025-02-03T05:53:45ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/128616128616The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation PregnanciesAlicia Martínez-Varea0Begoña Pellicer1Vicente Serra2David Hervás-Marín3Alicia Martínez-Romero4José Bellver5Alfredo Perales-Marín6Antonio Pellicer7Department of Obstetrics and Gynecology, University & Polytechnic Hospital La Fe, 46026 Valencia, SpainDepartment of Obstetrics and Gynecology, Valencia General University Hospital, 46014 Valencia, SpainValencian Infertility Institute, University of Valencia, 46015 Valencia, SpainBiostatistics Department, La Fe Health Research Institute, University & Polytechnic Hospital La Fe, 46026 Valencia, SpainCytomics Laboratory, Príncipe Felipe Research Centre, 46012 Valencia, SpainValencian Infertility Institute, University of Valencia, 46015 Valencia, SpainDepartment of Obstetrics and Gynecology, University & Polytechnic Hospital La Fe, 46026 Valencia, SpainDepartment of Obstetrics and Gynecology, University & Polytechnic Hospital La Fe, 46026 Valencia, SpainThis prospective longitudinal study aimed at comparing maternal immune response among naturally conceived (NC; n=25), in vitro fertilization (IVF; n=25), and egg donation (ED; n=25) pregnancies. The main outcome measures were, firstly, to follow up plasma levels of interleukin (IL) 1beta, IL2, IL4, IL5, IL6, IL8, IL10, IL17, interferon gamma, tumor necrosis factor-alpha (TNFα), transforming growth factor-beta (TGFβ), regulated upon activation normal T-cell expressed and secreted (RANTES), stromal cell-derived factor 1 alpha (SDF1α), and decidual granulocyte-macrophage colony-stimulating factor (GM-CSF) during the three trimesters of pregnancy during the three trimesters of pregnancy; secondly, to evaluate if the cytokine and chemokine pattern of ED pregnant women differs from that of those with autologous oocytes and, thirdly, to assess if women with preeclampsia show different cytokine and chemokine profile throughout pregnancy versus women with uneventful pregnancies. Pregnant women in the three study groups displayed similar cytokine and chemokine pattern throughout pregnancy. The levels of all quantified cytokines and chemokines, except RANTES, TNFα, IL8, TGFβ, and SDF1α, rose in the second trimester compared with the first, and these higher values remained in the third trimester. ED pregnancies showed lower SDF1α levels in the third trimester compared with NC and IVF pregnancies. Patients who developed preeclampsia displayed higher SDF1α plasma levels in the third trimester.http://dx.doi.org/10.1155/2015/128616 |
| spellingShingle | Alicia Martínez-Varea Begoña Pellicer Vicente Serra David Hervás-Marín Alicia Martínez-Romero José Bellver Alfredo Perales-Marín Antonio Pellicer The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies Journal of Immunology Research |
| title | The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies |
| title_full | The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies |
| title_fullStr | The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies |
| title_full_unstemmed | The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies |
| title_short | The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies |
| title_sort | maternal cytokine and chemokine profile of naturally conceived gestations is mainly preserved during in vitro fertilization and egg donation pregnancies |
| url | http://dx.doi.org/10.1155/2015/128616 |
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