Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration
Abstract Bone tissue engineering is pivotal in facilitating bone reconstruction by promoting persistent angiogenesis and osteogenesis. Initially, the hot gel composite hydrogel scaffold technique was employed. However, to address various limitations, numerous gel structures have since been developed...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | NPG Asia Materials |
| Online Access: | https://doi.org/10.1038/s41427-024-00533-z |
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| _version_ | 1832594622577115136 |
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| author | Wang Ding Yuxiang Ge Tikai Zhang Cheng Zhang Xiaofan Yin |
| author_facet | Wang Ding Yuxiang Ge Tikai Zhang Cheng Zhang Xiaofan Yin |
| author_sort | Wang Ding |
| collection | DOAJ |
| description | Abstract Bone tissue engineering is pivotal in facilitating bone reconstruction by promoting persistent angiogenesis and osteogenesis. Initially, the hot gel composite hydrogel scaffold technique was employed. However, to address various limitations, numerous gel structures have since been developed, including osteogenic gellan gels, semi-interpenetrating network hydrogels, photoinduced crosslinking methacrylate gels, and supramolecular hydrogels. This review examines the mechanisms, formation principles, and medical benefits of these gel structures. In addition, novel bioengineering techniques to regulate human bone growth are expected to emerge in the future. This work is expected to significantly expedite the advancement of hydrogel membranes in the field of bone repair. |
| format | Article |
| id | doaj-art-629993e812214cdcac27171181a9bff6 |
| institution | Kabale University |
| issn | 1884-4057 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | NPG Asia Materials |
| spelling | doaj-art-629993e812214cdcac27171181a9bff62025-01-19T12:28:37ZengNature PortfolioNPG Asia Materials1884-40572024-03-0116111810.1038/s41427-024-00533-zAdvanced construction strategies to obtain nanocomposite hydrogels for bone repair and regenerationWang Ding0Yuxiang Ge1Tikai Zhang2Cheng Zhang3Xiaofan Yin4Department of Orthopaedic Surgery, Minhang Hospital, Fudan UniversityDepartment of Orthopaedic Surgery, Minhang Hospital, Fudan UniversityInstitute of Nano and Biopolymeric Materials, School of Materials Science and Engineering, Tongji UniversityJiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application, School of Physical Science and Technology, Suzhou University of Science and TechnologyDepartment of Orthopaedic Surgery, Minhang Hospital, Fudan UniversityAbstract Bone tissue engineering is pivotal in facilitating bone reconstruction by promoting persistent angiogenesis and osteogenesis. Initially, the hot gel composite hydrogel scaffold technique was employed. However, to address various limitations, numerous gel structures have since been developed, including osteogenic gellan gels, semi-interpenetrating network hydrogels, photoinduced crosslinking methacrylate gels, and supramolecular hydrogels. This review examines the mechanisms, formation principles, and medical benefits of these gel structures. In addition, novel bioengineering techniques to regulate human bone growth are expected to emerge in the future. This work is expected to significantly expedite the advancement of hydrogel membranes in the field of bone repair.https://doi.org/10.1038/s41427-024-00533-z |
| spellingShingle | Wang Ding Yuxiang Ge Tikai Zhang Cheng Zhang Xiaofan Yin Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration NPG Asia Materials |
| title | Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration |
| title_full | Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration |
| title_fullStr | Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration |
| title_full_unstemmed | Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration |
| title_short | Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration |
| title_sort | advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration |
| url | https://doi.org/10.1038/s41427-024-00533-z |
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