A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases
Mendelian randomization (MR) is a statistical method that uses genetic variants as instrumental variables to estimate the causal effect of exposure on an outcome in the presence of unmeasured confounding. In this review, we argue that it is crucial to acknowledge the instrumental variable assumption...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society for the Study of Obesity
2025-01-01
|
| Series: | Journal of Obesity & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://www.jomes.org/journal/view.html?doi=10.7570/jomes24031 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590050926264320 |
|---|---|
| author | Seungjae Lee Woojoo Lee |
| author_facet | Seungjae Lee Woojoo Lee |
| author_sort | Seungjae Lee |
| collection | DOAJ |
| description | Mendelian randomization (MR) is a statistical method that uses genetic variants as instrumental variables to estimate the causal effect of exposure on an outcome in the presence of unmeasured confounding. In this review, we argue that it is crucial to acknowledge the instrumental variable assumptions in MR analysis. We describe widely used MR methods, using an example from obesity-related metabolic disorders. We describe situations in which instrumental variable assumptions are violated and explain how to evaluate these violations and employ robust methods for accommodating such violations. |
| format | Article |
| id | doaj-art-6296e7c681d0412cb154fae001431c74 |
| institution | Kabale University |
| issn | 2508-6235 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Society for the Study of Obesity |
| record_format | Article |
| series | Journal of Obesity & Metabolic Syndrome |
| spelling | doaj-art-6296e7c681d0412cb154fae001431c742025-01-24T03:28:56ZengKorean Society for the Study of ObesityJournal of Obesity & Metabolic Syndrome2508-62352025-01-01341142610.7570/jomes24031jomes24031A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related DiseasesSeungjae Lee0Woojoo Lee1Institute of Health and Environment, Seoul National University, Seoul, KoreaInstitute of Health and Environment, Seoul National University, Seoul, KoreaMendelian randomization (MR) is a statistical method that uses genetic variants as instrumental variables to estimate the causal effect of exposure on an outcome in the presence of unmeasured confounding. In this review, we argue that it is crucial to acknowledge the instrumental variable assumptions in MR analysis. We describe widely used MR methods, using an example from obesity-related metabolic disorders. We describe situations in which instrumental variable assumptions are violated and explain how to evaluate these violations and employ robust methods for accommodating such violations.http://www.jomes.org/journal/view.html?doi=10.7570/jomes24031causalityconfounding factorsepidemiologicgenetic pleiotropygenetic variationgenome-wide association studyhuman geneticsmendelian randomization analysis |
| spellingShingle | Seungjae Lee Woojoo Lee A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases Journal of Obesity & Metabolic Syndrome causality confounding factors epidemiologic genetic pleiotropy genetic variation genome-wide association study human genetics mendelian randomization analysis |
| title | A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases |
| title_full | A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases |
| title_fullStr | A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases |
| title_full_unstemmed | A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases |
| title_short | A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases |
| title_sort | review of mendelian randomization assumptions methods and application to obesity related diseases |
| topic | causality confounding factors epidemiologic genetic pleiotropy genetic variation genome-wide association study human genetics mendelian randomization analysis |
| url | http://www.jomes.org/journal/view.html?doi=10.7570/jomes24031 |
| work_keys_str_mv | AT seungjaelee areviewofmendelianrandomizationassumptionsmethodsandapplicationtoobesityrelateddiseases AT woojoolee areviewofmendelianrandomizationassumptionsmethodsandapplicationtoobesityrelateddiseases AT seungjaelee reviewofmendelianrandomizationassumptionsmethodsandapplicationtoobesityrelateddiseases AT woojoolee reviewofmendelianrandomizationassumptionsmethodsandapplicationtoobesityrelateddiseases |