Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy
Triple negative breast cancer is an aggressive form of breast cancer with limited treatment options and is without proven targeted therapy. Understanding the molecular basis of triple negative breast cancer is crucial for effective new drug development. Recent genomewide gene expression and DNA sequ...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/217185 |
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| _version_ | 1832559139404906496 |
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| author | Parvin F. Peddi Matthew J. Ellis Cynthia Ma |
| author_facet | Parvin F. Peddi Matthew J. Ellis Cynthia Ma |
| author_sort | Parvin F. Peddi |
| collection | DOAJ |
| description | Triple negative breast cancer is an aggressive form of breast cancer with limited treatment options and is without proven targeted therapy. Understanding the molecular basis of triple negative breast cancer is crucial for effective new drug development. Recent genomewide gene expression and DNA sequencing studies indicate that this cancer type is composed of a molecularly heterogeneous group of diseases that carry multiple somatic mutations and genomic structural changes. These findings have implications for therapeutic target identification and the design of future clinical trials for this aggressive group of breast cancer. |
| format | Article |
| id | doaj-art-629398dec0a64a8d80b0e7e027b6223f |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-629398dec0a64a8d80b0e7e027b6223f2025-02-03T01:30:46ZengWileyInternational Journal of Breast Cancer2090-31702090-31892012-01-01201210.1155/2012/217185217185Molecular Basis of Triple Negative Breast Cancer and Implications for TherapyParvin F. Peddi0Matthew J. Ellis1Cynthia Ma2Division of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USADivision of Oncology, Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USATriple negative breast cancer is an aggressive form of breast cancer with limited treatment options and is without proven targeted therapy. Understanding the molecular basis of triple negative breast cancer is crucial for effective new drug development. Recent genomewide gene expression and DNA sequencing studies indicate that this cancer type is composed of a molecularly heterogeneous group of diseases that carry multiple somatic mutations and genomic structural changes. These findings have implications for therapeutic target identification and the design of future clinical trials for this aggressive group of breast cancer.http://dx.doi.org/10.1155/2012/217185 |
| spellingShingle | Parvin F. Peddi Matthew J. Ellis Cynthia Ma Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy International Journal of Breast Cancer |
| title | Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy |
| title_full | Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy |
| title_fullStr | Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy |
| title_full_unstemmed | Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy |
| title_short | Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy |
| title_sort | molecular basis of triple negative breast cancer and implications for therapy |
| url | http://dx.doi.org/10.1155/2012/217185 |
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