Immune Evasion Strategies of Trypanosoma cruzi
Microbes have evolved a diverse range of strategies to subvert the host immune system. The protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease, provides a good example of such adaptations. This parasite targets a broad spectrum of host tissues including both peripheral and ce...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/178947 |
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| author | Ana Flávia Nardy Célio Geraldo Freire-de-Lima Alexandre Morrot |
| author_facet | Ana Flávia Nardy Célio Geraldo Freire-de-Lima Alexandre Morrot |
| author_sort | Ana Flávia Nardy |
| collection | DOAJ |
| description | Microbes have evolved a diverse range of strategies to subvert the host immune system. The protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease, provides a good example of such adaptations. This parasite targets a broad spectrum of host tissues including both peripheral and central lymphoid tissues. Rapid colonization of the host gives rise to a systemic acute response which the parasite must overcome. The parasite in fact undermines both innate and adaptive immunity. It interferes with the antigen presenting function of dendritic cells via an action on host sialic acid-binding Ig-like lectin receptors. These receptors also induce suppression of CD4+ T cells responses,
and we presented evidence that the sialylation of parasite-derived mucins is required for the inhibitory effects on CD4 T cells. In this review we highlight the major mechanisms used by Trypanosoma cruzi to overcome host immunity and discuss the role of parasite colonization of the central thymic lymphoid tissue in chronic disease. |
| format | Article |
| id | doaj-art-628e72b3f3fa4166a81371ff0a3b5aaf |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-628e72b3f3fa4166a81371ff0a3b5aaf2025-02-03T06:07:14ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/178947178947Immune Evasion Strategies of Trypanosoma cruziAna Flávia Nardy0Célio Geraldo Freire-de-Lima1Alexandre Morrot2Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21.941-590 Rio de Janeiro, RJ, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21.941-590 Rio de Janeiro, RJ, BrazilInstituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21.941-590 Rio de Janeiro, RJ, BrazilMicrobes have evolved a diverse range of strategies to subvert the host immune system. The protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease, provides a good example of such adaptations. This parasite targets a broad spectrum of host tissues including both peripheral and central lymphoid tissues. Rapid colonization of the host gives rise to a systemic acute response which the parasite must overcome. The parasite in fact undermines both innate and adaptive immunity. It interferes with the antigen presenting function of dendritic cells via an action on host sialic acid-binding Ig-like lectin receptors. These receptors also induce suppression of CD4+ T cells responses, and we presented evidence that the sialylation of parasite-derived mucins is required for the inhibitory effects on CD4 T cells. In this review we highlight the major mechanisms used by Trypanosoma cruzi to overcome host immunity and discuss the role of parasite colonization of the central thymic lymphoid tissue in chronic disease.http://dx.doi.org/10.1155/2015/178947 |
| spellingShingle | Ana Flávia Nardy Célio Geraldo Freire-de-Lima Alexandre Morrot Immune Evasion Strategies of Trypanosoma cruzi Journal of Immunology Research |
| title | Immune Evasion Strategies of Trypanosoma cruzi |
| title_full | Immune Evasion Strategies of Trypanosoma cruzi |
| title_fullStr | Immune Evasion Strategies of Trypanosoma cruzi |
| title_full_unstemmed | Immune Evasion Strategies of Trypanosoma cruzi |
| title_short | Immune Evasion Strategies of Trypanosoma cruzi |
| title_sort | immune evasion strategies of trypanosoma cruzi |
| url | http://dx.doi.org/10.1155/2015/178947 |
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