The Efficacy of Paxman Scalp Cooling System in Preventing Hair Loss in Breast Cancer Patients Receiving Chemotherapy in Western India – Multi-centre Retrospective Cohort Study
Aim: Chemotherapy-induced alopecia (CIA) is the most common side effect of systemic treatment in breast cancer patients. Scalp cooling gained worldwide acceptance in preventing or mitigating CIA in patients undergoing chemotherapy. The objective of this study was to evaluate the efficacy and safety...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Journal of Dermatology |
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| Online Access: | https://journals.lww.com/10.4103/ijd.ijd_345_23 |
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| author | Mangesh Mekha Ashish Joshi Vashishth Maniar Udip Maheshwari Kshitij Joshi Pritam Kalaskar Smit Sheth Pradip Kendre Disha Morzaria Reshma Korgavkar Chandrashekhar Pethe Sonal Dhande |
| author_facet | Mangesh Mekha Ashish Joshi Vashishth Maniar Udip Maheshwari Kshitij Joshi Pritam Kalaskar Smit Sheth Pradip Kendre Disha Morzaria Reshma Korgavkar Chandrashekhar Pethe Sonal Dhande |
| author_sort | Mangesh Mekha |
| collection | DOAJ |
| description | Aim:
Chemotherapy-induced alopecia (CIA) is the most common side effect of systemic treatment in breast cancer patients. Scalp cooling gained worldwide acceptance in preventing or mitigating CIA in patients undergoing chemotherapy. The objective of this study was to evaluate the efficacy and safety of the Paxman scalp cooling system (PSCS) in Indian breast cancer patients.
Materials and Methods:
This is a multi-centre, retrospective-observational study including patients registered from 1st March, 2019 to 30th April, 2021 undergoing chemotherapy for breast cancer by using PSCS. The primary end-point was the incidence of CIA after completing cycles of chemotherapy.
Results:
A total of 91 female patients were enrolled in the study, with a median age of 53 years (IQR: 44–62 years). The prevention of alopecia (grade 0 and grade I) was seen in 81%, while more than 50% hair loss (grade 2) was seen in 16.48% after completion of treatment. The univariate analysis results showed that CIA was significantly higher in patients who received anthracyclines (OR: 2.69; 95% CI: 1.04–6.958; P = 0.041) and in patients with a post-infusion cooling time of >150 minutes (OR: 8.409; 95% CI: 2.295–30.787; P = 0.001). The incidence of grade 2 (>50% hair loss) alopecia was 81.3% in patients <6 weeks and was 18.8% at >6 weeks of start of chemotherapy (P < 0.0001). No adverse events were reported in 71.4% of patients, and the most common adverse event was headache (18.7%).
Conclusion:
PSCS is an effective and well-tolerated treatment modality for preventing CIA among breast cancer patients undergoing chemotherapy. |
| format | Article |
| id | doaj-art-628bf63e04eb4315967bc6997b203fea |
| institution | Kabale University |
| issn | 0019-5154 1998-3611 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj-art-628bf63e04eb4315967bc6997b203fea2025-01-20T10:32:18ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112024-01-01691162310.4103/ijd.ijd_345_23The Efficacy of Paxman Scalp Cooling System in Preventing Hair Loss in Breast Cancer Patients Receiving Chemotherapy in Western India – Multi-centre Retrospective Cohort StudyMangesh MekhaAshish JoshiVashishth ManiarUdip MaheshwariKshitij JoshiPritam KalaskarSmit ShethPradip KendreDisha MorzariaReshma KorgavkarChandrashekhar PetheSonal DhandeAim: Chemotherapy-induced alopecia (CIA) is the most common side effect of systemic treatment in breast cancer patients. Scalp cooling gained worldwide acceptance in preventing or mitigating CIA in patients undergoing chemotherapy. The objective of this study was to evaluate the efficacy and safety of the Paxman scalp cooling system (PSCS) in Indian breast cancer patients. Materials and Methods: This is a multi-centre, retrospective-observational study including patients registered from 1st March, 2019 to 30th April, 2021 undergoing chemotherapy for breast cancer by using PSCS. The primary end-point was the incidence of CIA after completing cycles of chemotherapy. Results: A total of 91 female patients were enrolled in the study, with a median age of 53 years (IQR: 44–62 years). The prevention of alopecia (grade 0 and grade I) was seen in 81%, while more than 50% hair loss (grade 2) was seen in 16.48% after completion of treatment. The univariate analysis results showed that CIA was significantly higher in patients who received anthracyclines (OR: 2.69; 95% CI: 1.04–6.958; P = 0.041) and in patients with a post-infusion cooling time of >150 minutes (OR: 8.409; 95% CI: 2.295–30.787; P = 0.001). The incidence of grade 2 (>50% hair loss) alopecia was 81.3% in patients <6 weeks and was 18.8% at >6 weeks of start of chemotherapy (P < 0.0001). No adverse events were reported in 71.4% of patients, and the most common adverse event was headache (18.7%). Conclusion: PSCS is an effective and well-tolerated treatment modality for preventing CIA among breast cancer patients undergoing chemotherapy.https://journals.lww.com/10.4103/ijd.ijd_345_23anthracyclinesbreast cancerciapaxman scalp coolingpost-infusion cooling time |
| spellingShingle | Mangesh Mekha Ashish Joshi Vashishth Maniar Udip Maheshwari Kshitij Joshi Pritam Kalaskar Smit Sheth Pradip Kendre Disha Morzaria Reshma Korgavkar Chandrashekhar Pethe Sonal Dhande The Efficacy of Paxman Scalp Cooling System in Preventing Hair Loss in Breast Cancer Patients Receiving Chemotherapy in Western India – Multi-centre Retrospective Cohort Study Indian Journal of Dermatology anthracyclines breast cancer cia paxman scalp cooling post-infusion cooling time |
| title | The Efficacy of Paxman Scalp Cooling System in Preventing Hair Loss in Breast Cancer Patients Receiving Chemotherapy in Western India – Multi-centre Retrospective Cohort Study |
| title_full | The Efficacy of Paxman Scalp Cooling System in Preventing Hair Loss in Breast Cancer Patients Receiving Chemotherapy in Western India – Multi-centre Retrospective Cohort Study |
| title_fullStr | The Efficacy of Paxman Scalp Cooling System in Preventing Hair Loss in Breast Cancer Patients Receiving Chemotherapy in Western India – Multi-centre Retrospective Cohort Study |
| title_full_unstemmed | The Efficacy of Paxman Scalp Cooling System in Preventing Hair Loss in Breast Cancer Patients Receiving Chemotherapy in Western India – Multi-centre Retrospective Cohort Study |
| title_short | The Efficacy of Paxman Scalp Cooling System in Preventing Hair Loss in Breast Cancer Patients Receiving Chemotherapy in Western India – Multi-centre Retrospective Cohort Study |
| title_sort | efficacy of paxman scalp cooling system in preventing hair loss in breast cancer patients receiving chemotherapy in western india multi centre retrospective cohort study |
| topic | anthracyclines breast cancer cia paxman scalp cooling post-infusion cooling time |
| url | https://journals.lww.com/10.4103/ijd.ijd_345_23 |
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