Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up
Although some pituitary adenomas may have an aggressive behavior, the vast majority are benign. There are still controversies about predictive factors regarding the biological behavior of these particular tumors. This study evaluated potential markers of invasion and proliferation compared to curren...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/7964523 |
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| author | Juliano Coelho de Oliveira Zakir Luiz Augusto Casulari José Wilson Corrêa Rosa João Willy Corrêa Rosa Paulo Andrade de Mello Albino Verçosa de Magalhães Luciana Ansaneli Naves |
| author_facet | Juliano Coelho de Oliveira Zakir Luiz Augusto Casulari José Wilson Corrêa Rosa João Willy Corrêa Rosa Paulo Andrade de Mello Albino Verçosa de Magalhães Luciana Ansaneli Naves |
| author_sort | Juliano Coelho de Oliveira Zakir |
| collection | DOAJ |
| description | Although some pituitary adenomas may have an aggressive behavior, the vast majority are benign. There are still controversies about predictive factors regarding the biological behavior of these particular tumors. This study evaluated potential markers of invasion and proliferation compared to current classification patterns and epidemiogeographical parameters. The study included 50 patients, operated on for tumors greater than 30 mm, with a mean postoperative follow-up of 15.2 ± 4.8 years. Pituitary magnetic resonance was used to evaluate regrowth, invasion, and extension to adjacent tissue. Three tissue biomarkers were analyzed: p53, Ki-67, and c-erbB2. Tumors were classified according to a combination of histological and radiological features, ranging from noninvasive and nonproliferative (grade 1A) to invasive-proliferative (grade 2B). Tumors grades 2A and 2B represented 42% and 52%, respectively. Ki-67 (p=0.23) and c-erbB2 (p=0.71) had no significant relation to tumor progression status. P53 (p=0.003), parasellar invasion (p=0.03), and classification, grade 2B (p=0.01), were associated with worse clinical outcome. Parasellar invasion prevails as strong predictive factor of tumor recurrence. Severe suprasellar extension should be considered as invasion parameter and could impact prognosis. No environmental factors or geographical cluster were associated with tumor behavior. |
| format | Article |
| id | doaj-art-6287fb3064a147bb8c2b1a4b037065fc |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6287fb3064a147bb8c2b1a4b037065fc2025-02-03T01:02:37ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/79645237964523Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-UpJuliano Coelho de Oliveira Zakir0Luiz Augusto Casulari1José Wilson Corrêa Rosa2João Willy Corrêa Rosa3Paulo Andrade de Mello4Albino Verçosa de Magalhães5Luciana Ansaneli Naves6Department of Endocrinology, Faculty of Medicine, University of Brasilia, Brasilia, BrazilDepartment of Endocrinology, Faculty of Medicine, University of Brasilia, Brasilia, BrazilInstitute of Geosciences, University of Brasilia, Brasilia, BrazilInstitute of Geosciences, University of Brasilia, Brasilia, BrazilDepartment of Neurosurgery, Faculty of Medicine, University of Brasilia, Brasilia, BrazilDepartment of Pathology, Faculty of Medicine, University of Brasilia, Brasilia, BrazilDepartment of Endocrinology, Faculty of Medicine, University of Brasilia, Brasilia, BrazilAlthough some pituitary adenomas may have an aggressive behavior, the vast majority are benign. There are still controversies about predictive factors regarding the biological behavior of these particular tumors. This study evaluated potential markers of invasion and proliferation compared to current classification patterns and epidemiogeographical parameters. The study included 50 patients, operated on for tumors greater than 30 mm, with a mean postoperative follow-up of 15.2 ± 4.8 years. Pituitary magnetic resonance was used to evaluate regrowth, invasion, and extension to adjacent tissue. Three tissue biomarkers were analyzed: p53, Ki-67, and c-erbB2. Tumors were classified according to a combination of histological and radiological features, ranging from noninvasive and nonproliferative (grade 1A) to invasive-proliferative (grade 2B). Tumors grades 2A and 2B represented 42% and 52%, respectively. Ki-67 (p=0.23) and c-erbB2 (p=0.71) had no significant relation to tumor progression status. P53 (p=0.003), parasellar invasion (p=0.03), and classification, grade 2B (p=0.01), were associated with worse clinical outcome. Parasellar invasion prevails as strong predictive factor of tumor recurrence. Severe suprasellar extension should be considered as invasion parameter and could impact prognosis. No environmental factors or geographical cluster were associated with tumor behavior.http://dx.doi.org/10.1155/2016/7964523 |
| spellingShingle | Juliano Coelho de Oliveira Zakir Luiz Augusto Casulari José Wilson Corrêa Rosa João Willy Corrêa Rosa Paulo Andrade de Mello Albino Verçosa de Magalhães Luciana Ansaneli Naves Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up International Journal of Endocrinology |
| title | Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up |
| title_full | Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up |
| title_fullStr | Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up |
| title_full_unstemmed | Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up |
| title_short | Prognostic Value of Invasion, Markers of Proliferation, and Classification of Giant Pituitary Tumors, in a Georeferred Cohort in Brazil of 50 Patients, with a Long-Term Postoperative Follow-Up |
| title_sort | prognostic value of invasion markers of proliferation and classification of giant pituitary tumors in a georeferred cohort in brazil of 50 patients with a long term postoperative follow up |
| url | http://dx.doi.org/10.1155/2016/7964523 |
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