Infections Caused by Actinomyces neuii: A Case Series and Review of an Unusual Bacterium
Background. Actinomyces neuii is a Gram-positive bacillus rarely implicated in human infections. However, its occurrence is being increasingly recognized with the use of improved identification systems. Objective. To analyse A. neuii infections in Alberta, Canada, and review the literature regarding...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2016/6017605 |
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| _version_ | 1832556338438209536 |
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| author | Nathan Zelyas Susan Gee Barb Nilsson Tracy Bennett Robert Rennie |
| author_facet | Nathan Zelyas Susan Gee Barb Nilsson Tracy Bennett Robert Rennie |
| author_sort | Nathan Zelyas |
| collection | DOAJ |
| description | Background. Actinomyces neuii is a Gram-positive bacillus rarely implicated in human infections. However, its occurrence is being increasingly recognized with the use of improved identification systems. Objective. To analyse A. neuii infections in Alberta, Canada, and review the literature regarding this unusual pathogen. Methods. Cases of A. neuii were identified in 2013-2014 in Alberta. Samples were cultured aerobically and anaerobically. A predominant catalase positive Gram-positive coryneform bacillus with no branching was isolated in each case. Testing was initially done with API-CORYNE® (bioMérieux) and isolates were sent to the Provincial Laboratory for Public Health for further testing. Isolates’ identities were confirmed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry microbial identification system (MALDI-TOF MS MIS; bioMérieux) and/or DNA sequencing. Results. Six cases of A. neuii infection were identified. All patients had soft tissue infections; typically, incision and drainage were done followed by a course of antibiotics. Agents used included cephalexin, ertapenem, ciprofloxacin, and clindamycin. All had favourable outcomes. Conclusions. While A. neuii is infrequently recognized, it can cause a diverse array of infections. Increased use of MALDI-TOF MS MIS is leading to increased detection; thus, understanding the pathogenicity of this bacterium and its typical susceptibility profile will aid clinical decision-making. |
| format | Article |
| id | doaj-art-6286c504bd3845fcaa004724eb627191 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-6286c504bd3845fcaa004724eb6271912025-02-03T05:45:44ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932016-01-01201610.1155/2016/60176056017605Infections Caused by Actinomyces neuii: A Case Series and Review of an Unusual BacteriumNathan Zelyas0Susan Gee1Barb Nilsson2Tracy Bennett3Robert Rennie4Provincial Laboratory for Public Health, Walter Mackenzie Health Sciences Centre, University of Alberta Hospital, 8440-112 Street, Edmonton, AB, T6G 2J2, CanadaProvincial Laboratory for Public Health, Walter Mackenzie Health Sciences Centre, University of Alberta Hospital, 8440-112 Street, Edmonton, AB, T6G 2J2, CanadaQueen Elizabeth II Hospital, 10409-98 Street, Grande Prairie, AB, T8V 2E8, CanadaRed Deer Regional Hospital, 3942-50a Avenue, Red Deer, AB, T4N 4E7, CanadaProvincial Laboratory for Public Health, Walter Mackenzie Health Sciences Centre, University of Alberta Hospital, 8440-112 Street, Edmonton, AB, T6G 2J2, CanadaBackground. Actinomyces neuii is a Gram-positive bacillus rarely implicated in human infections. However, its occurrence is being increasingly recognized with the use of improved identification systems. Objective. To analyse A. neuii infections in Alberta, Canada, and review the literature regarding this unusual pathogen. Methods. Cases of A. neuii were identified in 2013-2014 in Alberta. Samples were cultured aerobically and anaerobically. A predominant catalase positive Gram-positive coryneform bacillus with no branching was isolated in each case. Testing was initially done with API-CORYNE® (bioMérieux) and isolates were sent to the Provincial Laboratory for Public Health for further testing. Isolates’ identities were confirmed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry microbial identification system (MALDI-TOF MS MIS; bioMérieux) and/or DNA sequencing. Results. Six cases of A. neuii infection were identified. All patients had soft tissue infections; typically, incision and drainage were done followed by a course of antibiotics. Agents used included cephalexin, ertapenem, ciprofloxacin, and clindamycin. All had favourable outcomes. Conclusions. While A. neuii is infrequently recognized, it can cause a diverse array of infections. Increased use of MALDI-TOF MS MIS is leading to increased detection; thus, understanding the pathogenicity of this bacterium and its typical susceptibility profile will aid clinical decision-making.http://dx.doi.org/10.1155/2016/6017605 |
| spellingShingle | Nathan Zelyas Susan Gee Barb Nilsson Tracy Bennett Robert Rennie Infections Caused by Actinomyces neuii: A Case Series and Review of an Unusual Bacterium Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Infections Caused by Actinomyces neuii: A Case Series and Review of an Unusual Bacterium |
| title_full | Infections Caused by Actinomyces neuii: A Case Series and Review of an Unusual Bacterium |
| title_fullStr | Infections Caused by Actinomyces neuii: A Case Series and Review of an Unusual Bacterium |
| title_full_unstemmed | Infections Caused by Actinomyces neuii: A Case Series and Review of an Unusual Bacterium |
| title_short | Infections Caused by Actinomyces neuii: A Case Series and Review of an Unusual Bacterium |
| title_sort | infections caused by actinomyces neuii a case series and review of an unusual bacterium |
| url | http://dx.doi.org/10.1155/2016/6017605 |
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