Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice
According to the proportion of 1:1, konjac flour and mulberry leaf powder are compounded into a kind of dietary fiber source (KMCP). It is found to be good for anti-inflammation. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In our work, the effect of KMCP on aller...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000265 |
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| author | Yiyun Zhang Jinxing Wang Qi Zhang Liling Deng Siyao Miao Geng Zhong |
| author_facet | Yiyun Zhang Jinxing Wang Qi Zhang Liling Deng Siyao Miao Geng Zhong |
| author_sort | Yiyun Zhang |
| collection | DOAJ |
| description | According to the proportion of 1:1, konjac flour and mulberry leaf powder are compounded into a kind of dietary fiber source (KMCP). It is found to be good for anti-inflammation. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In our work, the effect of KMCP on allergic rhinitis (AR) induced by ovalbumin (OVA) was investigated. We found that the number of nasal rubbing and sneezing, the eosinophil (EOS) count in the nasal mucosa, and the serum levels of histamine (HIS), OVA-specific immunoglobulin E (OVA-sIgE) and interleukin-4 (IL-4) were decreased, and the histopathological changes of nasal mucosa were inhibited. Additionally, the experiments further proved that the KMCP treatment could exert substantial effects on short-chain fatty acids (SCFAs) metabolism in the cecum as well. Overall findings suggest that KMCP could suppress the inflammatory response in AR mice, and serve as a novel curative therapeutic for AR without side effects. |
| format | Article |
| id | doaj-art-625c23c101654508aa53e21da9e72e2d |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-625c23c101654508aa53e21da9e72e2d2025-02-03T00:27:37ZengTsinghua University PressFood Science and Human Wellness2213-45302023-09-0112516741682Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c miceYiyun Zhang0Jinxing Wang1Qi Zhang2Liling Deng3Siyao Miao4Geng Zhong5College of Food Science, Southwest University, Chongqing 400715, China; WESTA College, Southwest University, Chongqing 400715, ChinaCollege of Food Science, Southwest University, Chongqing 400715, ChinaCollege of Food Science, Southwest University, Chongqing 400715, ChinaCollege of Food Science, Southwest University, Chongqing 400715, China; Chongqing Institute of Biotechnology Co., Ltd., Chongqing 401121, ChinaWESTA College, Southwest University, Chongqing 400715, ChinaCollege of Food Science, Southwest University, Chongqing 400715, China; National Undergraduate Experimental Teaching Demonstration Center of Food Science and Engineering, Southwest University, Chongqing 400715, China; Corresponding author at: College of Food Science, Southwest University, Chongqing 400715, China.According to the proportion of 1:1, konjac flour and mulberry leaf powder are compounded into a kind of dietary fiber source (KMCP). It is found to be good for anti-inflammation. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In our work, the effect of KMCP on allergic rhinitis (AR) induced by ovalbumin (OVA) was investigated. We found that the number of nasal rubbing and sneezing, the eosinophil (EOS) count in the nasal mucosa, and the serum levels of histamine (HIS), OVA-specific immunoglobulin E (OVA-sIgE) and interleukin-4 (IL-4) were decreased, and the histopathological changes of nasal mucosa were inhibited. Additionally, the experiments further proved that the KMCP treatment could exert substantial effects on short-chain fatty acids (SCFAs) metabolism in the cecum as well. Overall findings suggest that KMCP could suppress the inflammatory response in AR mice, and serve as a novel curative therapeutic for AR without side effects.http://www.sciencedirect.com/science/article/pii/S2213453023000265Konjac-mulberry leaf compound powderAllergic rhinitisInflammatory responseShort-chain fatty acids |
| spellingShingle | Yiyun Zhang Jinxing Wang Qi Zhang Liling Deng Siyao Miao Geng Zhong Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice Food Science and Human Wellness Konjac-mulberry leaf compound powder Allergic rhinitis Inflammatory response Short-chain fatty acids |
| title | Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice |
| title_full | Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice |
| title_fullStr | Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice |
| title_full_unstemmed | Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice |
| title_short | Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice |
| title_sort | konjac mulberry leaf compound powder alleviates ova induced allergic rhinitis in balb c mice |
| topic | Konjac-mulberry leaf compound powder Allergic rhinitis Inflammatory response Short-chain fatty acids |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000265 |
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