Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice
Baicalein (BC), a flavonoid, which lacks the qualities of reproductive health and shows adverse effects, is tested in this study. Inseminated mice were injected with 30, 60, and 90 mg BC/Kg body weight on gestation days 11, 13, 15, and 17. The F1 BC-exposed males of each dosage were divided into six...
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| Format: | Article |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/5012736 |
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| author | Sridevi Vaadala Naveen Ponneri Venkata Shashank Karanam Sri Bhashyam Sainath Pamanji Sreenivasuala Reddy Ramachandra Reddy Pamuru Arifullah Mohammed |
| author_facet | Sridevi Vaadala Naveen Ponneri Venkata Shashank Karanam Sri Bhashyam Sainath Pamanji Sreenivasuala Reddy Ramachandra Reddy Pamuru Arifullah Mohammed |
| author_sort | Sridevi Vaadala |
| collection | DOAJ |
| description | Baicalein (BC), a flavonoid, which lacks the qualities of reproductive health and shows adverse effects, is tested in this study. Inseminated mice were injected with 30, 60, and 90 mg BC/Kg body weight on gestation days 11, 13, 15, and 17. The F1 BC-exposed males of each dosage were divided into six groups. First three groups (n = 6 from each BC dosage) were used for assessment of reproductive performance, the others (n = 4 from each BC dosage) were administered with testosterone 4.16 mg/kg body weight on postnatal days 21, 31, and 41. The reproductive health of adult F1 males at the age of 55 and 60 was tested. Prenatal BC exposure showed reduced fertility after cohabitation with control females. The BC exposure significantly reduced the body weight, tissue indices, and sperm parameters (motility, count, viability, and daily sperm count) and altered the sperm membrane in a hypoosmotic swelling test. A downward trend was observed in testicular steroidogenic marker enzymes (3β- and 17β-steroid dehydrogenases) and serum testosterone, whereas increase in serum titers of FSH and LH along with altered the testicular histology. Conversely, testosterone (4.16 mg/kg body weight) partially recovered reduced male reproductive health by BC. BC impaired male reproductive health due to low levels of testosterone is reverted by external testosterone is evidenced in this study. |
| format | Article |
| id | doaj-art-62559fa4a54549028ccfb17c6743ff1d |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-62559fa4a54549028ccfb17c6743ff1d2025-02-03T01:25:46ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/50127365012736Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male MiceSridevi Vaadala0Naveen Ponneri1Venkata Shashank Karanam2Sri Bhashyam Sainath3Pamanji Sreenivasuala Reddy4Ramachandra Reddy Pamuru5Arifullah Mohammed6Department of Biochemistry, Yogi Vemana University, Vemanapuram, Kadapa 516 005, AP, IndiaDepartment of Biochemistry, Yogi Vemana University, Vemanapuram, Kadapa 516 005, AP, IndiaWest High School, Torrance 90503, CA, USADepartment of Biotechnology, Vikrama Simhapuri University, Kakutur, P. S. Nellore 524 320, AP, IndiaDepartment of Zoology, Sri Venkateswara University, Tirupati 517 502, AP, IndiaDepartment of Biochemistry, Yogi Vemana University, Vemanapuram, Kadapa 516 005, AP, IndiaInstitute of Food Security and Sustainable Agriculture (IFSSA), Universiti Malaysia Kelantan Campus Jeli, Locked Bag 100, Jeli 17600, Kelantan, MalaysiaBaicalein (BC), a flavonoid, which lacks the qualities of reproductive health and shows adverse effects, is tested in this study. Inseminated mice were injected with 30, 60, and 90 mg BC/Kg body weight on gestation days 11, 13, 15, and 17. The F1 BC-exposed males of each dosage were divided into six groups. First three groups (n = 6 from each BC dosage) were used for assessment of reproductive performance, the others (n = 4 from each BC dosage) were administered with testosterone 4.16 mg/kg body weight on postnatal days 21, 31, and 41. The reproductive health of adult F1 males at the age of 55 and 60 was tested. Prenatal BC exposure showed reduced fertility after cohabitation with control females. The BC exposure significantly reduced the body weight, tissue indices, and sperm parameters (motility, count, viability, and daily sperm count) and altered the sperm membrane in a hypoosmotic swelling test. A downward trend was observed in testicular steroidogenic marker enzymes (3β- and 17β-steroid dehydrogenases) and serum testosterone, whereas increase in serum titers of FSH and LH along with altered the testicular histology. Conversely, testosterone (4.16 mg/kg body weight) partially recovered reduced male reproductive health by BC. BC impaired male reproductive health due to low levels of testosterone is reverted by external testosterone is evidenced in this study.http://dx.doi.org/10.1155/2020/5012736 |
| spellingShingle | Sridevi Vaadala Naveen Ponneri Venkata Shashank Karanam Sri Bhashyam Sainath Pamanji Sreenivasuala Reddy Ramachandra Reddy Pamuru Arifullah Mohammed Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice International Journal of Endocrinology |
| title | Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice |
| title_full | Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice |
| title_fullStr | Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice |
| title_full_unstemmed | Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice |
| title_short | Recovery of Prenatal Baicalein Exposure Perturbed Reproduction by Postnatal Exposure of Testosterone in Male Mice |
| title_sort | recovery of prenatal baicalein exposure perturbed reproduction by postnatal exposure of testosterone in male mice |
| url | http://dx.doi.org/10.1155/2020/5012736 |
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