Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review
The aim of the study was to assess the effect of vitamin D-binding protein (DBP) polymorphism on coronary artery disease (CAD). DBP phenotypes were identified in the groups: control (n=306), men suffering from CAD (n=154), and long-lived individuals (n=108). Isoelectric focusing of DBP phenotypes in...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/8347379 |
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| author | Donatas Stakisaitis Vita Lesauskaitė Milda Girdauskaitė Ernestas Janulionis Albertas Ulys Rimantas Benetis |
| author_facet | Donatas Stakisaitis Vita Lesauskaitė Milda Girdauskaitė Ernestas Janulionis Albertas Ulys Rimantas Benetis |
| author_sort | Donatas Stakisaitis |
| collection | DOAJ |
| description | The aim of the study was to assess the effect of vitamin D-binding protein (DBP) polymorphism on coronary artery disease (CAD). DBP phenotypes were identified in the groups: control (n=306), men suffering from CAD (n=154), and long-lived individuals (n=108). Isoelectric focusing of DBP phenotypes in serum was performed on polyacrylamide gel. Distribution of DBP phenotypes in the study groups was found to be in Hardy-Weinberg equilibrium. Gc1s-1s phenotype and Gc1s allele frequency in CAD groups were significantly higher than in control, and Gc1s allele frequency was found significantly more often in CAD compared with long-lived group (p<0.05). The Gc2 allele frequency in control was higher as compared with Gc2 frequency in CAD group (p<0.05). The Gc2-2 phenotype was more frequent in long-lived survivors than in the CAD group (p<0.05). It was found that the Gc1s allele significantly increased the risk of CAD with the odds ratio (OR) equal to 1.45 (p<0.02) and showed Gc2 to be related with a decreased risk of CAD (OR = 0.69; p<0.03). Authors review the role of DBP in resistance to atherosclerosis and cancer as the main longevity determinants. |
| format | Article |
| id | doaj-art-62533503bb7747f295248c28f9aa23a9 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-62533503bb7747f295248c28f9aa23a92025-02-03T01:21:53ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/83473798347379Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a ReviewDonatas Stakisaitis0Vita Lesauskaitė1Milda Girdauskaitė2Ernestas Janulionis3Albertas Ulys4Rimantas Benetis5Laboratory of Cancerogenesis and Cancer Epidemiology, Scientific Research Center, National Cancer Institute, Santariskiu 1, LT-08660 Vilnius, LithuaniaDepartment of Geriatrics, Medical Academy, Lithuanian University of Health Sciences, A. Mickevičiaus 9, LT-44307 Kaunas, LithuaniaLaboratory of Cancerogenesis and Cancer Epidemiology, Scientific Research Center, National Cancer Institute, Santariskiu 1, LT-08660 Vilnius, LithuaniaRadiation and Medical Oncology Clinics, National Cancer Institute, Santariskiu 1, LT-08660 Vilnius, LithuaniaOncosurgery Clinics, National Cancer Institute, Santariskiu 1, LT-08660 Vilnius, LithuaniaInstitute of Cardiology of the Medical Academy, Lithuanian University of Health Sciences, Sukileliu 17, LT-50161 Kaunas, LithuaniaThe aim of the study was to assess the effect of vitamin D-binding protein (DBP) polymorphism on coronary artery disease (CAD). DBP phenotypes were identified in the groups: control (n=306), men suffering from CAD (n=154), and long-lived individuals (n=108). Isoelectric focusing of DBP phenotypes in serum was performed on polyacrylamide gel. Distribution of DBP phenotypes in the study groups was found to be in Hardy-Weinberg equilibrium. Gc1s-1s phenotype and Gc1s allele frequency in CAD groups were significantly higher than in control, and Gc1s allele frequency was found significantly more often in CAD compared with long-lived group (p<0.05). The Gc2 allele frequency in control was higher as compared with Gc2 frequency in CAD group (p<0.05). The Gc2-2 phenotype was more frequent in long-lived survivors than in the CAD group (p<0.05). It was found that the Gc1s allele significantly increased the risk of CAD with the odds ratio (OR) equal to 1.45 (p<0.02) and showed Gc2 to be related with a decreased risk of CAD (OR = 0.69; p<0.03). Authors review the role of DBP in resistance to atherosclerosis and cancer as the main longevity determinants.http://dx.doi.org/10.1155/2016/8347379 |
| spellingShingle | Donatas Stakisaitis Vita Lesauskaitė Milda Girdauskaitė Ernestas Janulionis Albertas Ulys Rimantas Benetis Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review International Journal of Endocrinology |
| title | Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review |
| title_full | Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review |
| title_fullStr | Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review |
| title_full_unstemmed | Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review |
| title_short | Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review |
| title_sort | investigation of vitamin d binding protein polymorphism impact on coronary artery disease and relationship with longevity own data and a review |
| url | http://dx.doi.org/10.1155/2016/8347379 |
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