Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity
The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR,...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0011 |
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| author | Ciocilteu Maria-Viorica Mocanu Andreea Gabriela Mocanu Adriana Ducu Catalin Nicolaescu Oana Elena Manda Valentin Costel Turcu-Stiolica Adina Nicolicescu Claudiu Melinte Razvan Balasoiu Maria Croitoru Octavian Neamtu Johny |
| author_facet | Ciocilteu Maria-Viorica Mocanu Andreea Gabriela Mocanu Adriana Ducu Catalin Nicolaescu Oana Elena Manda Valentin Costel Turcu-Stiolica Adina Nicolicescu Claudiu Melinte Razvan Balasoiu Maria Croitoru Octavian Neamtu Johny |
| author_sort | Ciocilteu Maria-Viorica |
| collection | DOAJ |
| description | The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18.13 %). The in vitro release study (Higuchi model C = K t1/2 and Ritger-Peppas model, C = K t0.6) showed a diffusion-controlled mechanism. The antibacterial activity showed that the bacterial growth inhibition zones were approximately equal for the synthesis composites and for the mechanical mixture on the Staphylococcus aureus germ. |
| format | Article |
| id | doaj-art-624a04e88caf42aea314e02a6bb43e3a |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-624a04e88caf42aea314e02a6bb43e3a2025-02-02T11:49:57ZengSciendoActa Pharmaceutica1846-95582018-06-0168212914410.2478/acph-2018-0011acph-2018-0011Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activityCiocilteu Maria-Viorica0Mocanu Andreea Gabriela1Mocanu Adriana2Ducu Catalin3Nicolaescu Oana Elena4Manda Valentin Costel5Turcu-Stiolica Adina6Nicolicescu Claudiu7Melinte Razvan8Balasoiu Maria9Croitoru Octavian10Neamtu Johny11University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj)RomaniaUniversity of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj)RomaniaUniversity of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj)RomaniaCS I, Global Research S.R.L., Piteşti, RomaniaUniversity of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj)RomaniaUniversity of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj)RomaniaUniversity of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj)RomaniaUniversity of Craiova, Faculty of Mechanics Department of IMST, 220037, Drobeta Turnu Severin (Mehedinti), RomaniaUniversity of Medicine and Pharmacy of Craiova, Faculty of Medicine, Craiova (Dolj)RomaniaUniversity of Medicine and Pharmacy of Craiova, Faculty of Medicine, Craiova (Dolj)RomaniaUniversity of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj)RomaniaUniversity of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Craiova (Dolj)RomaniaThe main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18.13 %). The in vitro release study (Higuchi model C = K t1/2 and Ritger-Peppas model, C = K t0.6) showed a diffusion-controlled mechanism. The antibacterial activity showed that the bacterial growth inhibition zones were approximately equal for the synthesis composites and for the mechanical mixture on the Staphylococcus aureus germ.https://doi.org/10.2478/acph-2018-0011hydroxiapatite-ciprofloxacin compositeswet precipitation synthesisin vitro release profileantibacterial activity |
| spellingShingle | Ciocilteu Maria-Viorica Mocanu Andreea Gabriela Mocanu Adriana Ducu Catalin Nicolaescu Oana Elena Manda Valentin Costel Turcu-Stiolica Adina Nicolicescu Claudiu Melinte Razvan Balasoiu Maria Croitoru Octavian Neamtu Johny Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity Acta Pharmaceutica hydroxiapatite-ciprofloxacin composites wet precipitation synthesis in vitro release profile antibacterial activity |
| title | Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity |
| title_full | Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity |
| title_fullStr | Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity |
| title_full_unstemmed | Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity |
| title_short | Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity |
| title_sort | hydroxyapatite ciprofloxacin delivery system synthesis characterisation and antibacterial activity |
| topic | hydroxiapatite-ciprofloxacin composites wet precipitation synthesis in vitro release profile antibacterial activity |
| url | https://doi.org/10.2478/acph-2018-0011 |
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