Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia
Abstract The mosquito-lethal effect of commercially available standard and long-lasting ivermectin formulations were evaluated in cattle and buffalo against wild-caught Anopheles on Sumba Island, Indonesia. Cattle have substantially higher blood-level concentrations of ivermectin compared to buffalo...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-81743-x |
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| author | Kevin C. Kobylinski Tri B. T. Satoto Wisnu Nurcahyo Yudi Ratna Nugraheni Vincentius A. Testamenti I Putu B. A. Winata Yosua L. Pono Diana Timoria Piyanan Assawasuwannakit Mary Chambers J. Kevin Baird Joel Tarning Lorenz von Seidlein Claus Bøgh |
| author_facet | Kevin C. Kobylinski Tri B. T. Satoto Wisnu Nurcahyo Yudi Ratna Nugraheni Vincentius A. Testamenti I Putu B. A. Winata Yosua L. Pono Diana Timoria Piyanan Assawasuwannakit Mary Chambers J. Kevin Baird Joel Tarning Lorenz von Seidlein Claus Bøgh |
| author_sort | Kevin C. Kobylinski |
| collection | DOAJ |
| description | Abstract The mosquito-lethal effect of commercially available standard and long-lasting ivermectin formulations were evaluated in cattle and buffalo against wild-caught Anopheles on Sumba Island, Indonesia. Cattle have substantially higher blood-level concentrations of ivermectin compared to buffalo after receiving similar doses, irrespective of formulation. In total, nine Anopheles species were captured to assess the mosquito-lethal effects of ivermectin with susceptibility ranked from lowest to highest: An. flavirostris < An. aconitus < An. annularis < An. tessellatus < An. maculatus < An. sundaicus < An. vagus < An. kochi < An. barbirostris. The duration of mosquito-lethal effect of long-lasting ivermectin was superior to standard ivermectin and in cattle it well exceeded the WHO criteria for new endectocides having a mortality hazard ratio greater than 4 through 30 days after administration. Buffalo may require higher doses of long-lasting ivermectin to achieve similar mosquito-lethal effects observed in cattle. Of the four hosts evaluated buffalo were the most attractive to Anopheles followed by cattle then horse and finally humans. This study demonstrates, for the first time, the superiority of a commercially available long-lasting ivermectin formulation for the potential deployment of mass ivermectin treatment of livestock as a vector control tool for malaria elimination in Southeast Asia. |
| format | Article |
| id | doaj-art-621e59cb959e417d8c4a4c33f9387017 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-621e59cb959e417d8c4a4c33f93870172025-02-02T12:24:59ZengNature PortfolioScientific Reports2045-23222024-11-0114111410.1038/s41598-024-81743-xImpact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, IndonesiaKevin C. Kobylinski0Tri B. T. Satoto1Wisnu Nurcahyo2Yudi Ratna Nugraheni3Vincentius A. Testamenti4I Putu B. A. Winata5Yosua L. Pono6Diana Timoria7Piyanan Assawasuwannakit8Mary Chambers9J. Kevin Baird10Joel Tarning11Lorenz von Seidlein12Claus Bøgh13Mahidol Oxford Tropical Medicine Research Unit, Mahidol UniversityCenter for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MadaDepartment of Parasitology, Faculty of Veterinary Medicine, Universitas Gadjah MadahDepartment of Parasitology, Faculty of Veterinary Medicine, Universitas Gadjah MadahCenter for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah MadaSouthwest Sumba Livestock and Animal Health OfficeSouthwest Sumba Livestock and Animal Health OfficeOxford University Clinical Research UnitMahidol Oxford Tropical Medicine Research Unit, Mahidol UniversityOxford University Clinical Research UnitCentre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of OxfordMahidol Oxford Tropical Medicine Research Unit, Mahidol UniversityMahidol Oxford Tropical Medicine Research Unit, Mahidol UniversityThe Sumba FoundationAbstract The mosquito-lethal effect of commercially available standard and long-lasting ivermectin formulations were evaluated in cattle and buffalo against wild-caught Anopheles on Sumba Island, Indonesia. Cattle have substantially higher blood-level concentrations of ivermectin compared to buffalo after receiving similar doses, irrespective of formulation. In total, nine Anopheles species were captured to assess the mosquito-lethal effects of ivermectin with susceptibility ranked from lowest to highest: An. flavirostris < An. aconitus < An. annularis < An. tessellatus < An. maculatus < An. sundaicus < An. vagus < An. kochi < An. barbirostris. The duration of mosquito-lethal effect of long-lasting ivermectin was superior to standard ivermectin and in cattle it well exceeded the WHO criteria for new endectocides having a mortality hazard ratio greater than 4 through 30 days after administration. Buffalo may require higher doses of long-lasting ivermectin to achieve similar mosquito-lethal effects observed in cattle. Of the four hosts evaluated buffalo were the most attractive to Anopheles followed by cattle then horse and finally humans. This study demonstrates, for the first time, the superiority of a commercially available long-lasting ivermectin formulation for the potential deployment of mass ivermectin treatment of livestock as a vector control tool for malaria elimination in Southeast Asia.https://doi.org/10.1038/s41598-024-81743-xAnophelesLivestockIvermectinLong-lastingSurvivalSumba |
| spellingShingle | Kevin C. Kobylinski Tri B. T. Satoto Wisnu Nurcahyo Yudi Ratna Nugraheni Vincentius A. Testamenti I Putu B. A. Winata Yosua L. Pono Diana Timoria Piyanan Assawasuwannakit Mary Chambers J. Kevin Baird Joel Tarning Lorenz von Seidlein Claus Bøgh Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia Scientific Reports Anopheles Livestock Ivermectin Long-lasting Survival Sumba |
| title | Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia |
| title_full | Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia |
| title_fullStr | Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia |
| title_full_unstemmed | Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia |
| title_short | Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia |
| title_sort | impact of standard and long lasting ivermectin formulations in cattle and buffalo on wild anopheles survival on sumba island indonesia |
| topic | Anopheles Livestock Ivermectin Long-lasting Survival Sumba |
| url | https://doi.org/10.1038/s41598-024-81743-x |
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