Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study
Abstract We aimed to assess the association of tramadol use with the risk of dementia. This population-based retrospective cohort study using the Korean National Health Insurance Service database included a total of 1,865,827 older adult patients aged 60 years or older with common musculoskeletal pa...
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Nature Portfolio
2024-10-01
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| Online Access: | https://doi.org/10.1038/s41598-024-74817-3 |
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| author | Si Nae Oh Hye Jun Kim Jae Yong Shim Kyuwoong Kim Seogsong Jeong Sun Jae Park Sang Hyun Lee Joong Won Ha Sang Min Park |
| author_facet | Si Nae Oh Hye Jun Kim Jae Yong Shim Kyuwoong Kim Seogsong Jeong Sun Jae Park Sang Hyun Lee Joong Won Ha Sang Min Park |
| author_sort | Si Nae Oh |
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| description | Abstract We aimed to assess the association of tramadol use with the risk of dementia. This population-based retrospective cohort study using the Korean National Health Insurance Service database included a total of 1,865,827 older adult patients aged 60 years or older with common musculoskeletal pain between January 1, 2003, and December 31, 2007. Individuals who were newly dispensed tramadol (N = 41,963) were identified and propensity score–matched with those who were not (N = 41,963). Over a maximum of 14-year follow-up, the incidence rates (events per 1000 person-years) of all-cause dementia were 6.1 for nonusers, 6.2 for those with cumulative tramadol use of 1–14 days, 7.7 for those with 15–90 days of use, and 8.0 for those with > 90 days of use. Longer cumulative duration of tramadol use was associated with an increased risk of all-cause dementia compared with nonuse (1 to 14 days: aHR 1.06, 95% CI 0.96–1.17; 15 to 90 days: aHR 1.14, 95% CI 1.10–1.35; and more than 90 days: aHR 1.18, 95% CI 1.00–1.39; test for trend: P < 0.001). The results showed a similar pattern for Alzheimer’s disease and were robust across subgroup and sensitivity analyses, but not for vascular dementia. This study found that exposure to tramadol was associated with an increased risk of dementia. Taking this potential risk into consideration, clinicians should carefully weigh potential benefits and risks when prescribing tramadol to older adults with musculoskeletal pain. |
| format | Article |
| id | doaj-art-621840d7e9ba4a3695bdf7a4ae0b7e98 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-621840d7e9ba4a3695bdf7a4ae0b7e982025-01-26T12:34:36ZengNature PortfolioScientific Reports2045-23222024-10-011411810.1038/s41598-024-74817-3Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort studySi Nae Oh0Hye Jun Kim1Jae Yong Shim2Kyuwoong Kim3Seogsong Jeong4Sun Jae Park5Sang Hyun Lee6Joong Won Ha7Sang Min Park8Department of Family Medicine, National Health Insurance Service Ilsan HospitalDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Medicine, Yonsei University Graduate SchoolNational Cancer Control Institute, National Cancer CenterDepartment of Biomedical Informatics, Korea University College of MedicineDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Family Medicine, National Health Insurance Service Ilsan HospitalDepartment of Orthopedic Surgery, National Health Insurance Service Ilsan HospitalDepartment of Biomedical Sciences, Seoul National University Graduate SchoolAbstract We aimed to assess the association of tramadol use with the risk of dementia. This population-based retrospective cohort study using the Korean National Health Insurance Service database included a total of 1,865,827 older adult patients aged 60 years or older with common musculoskeletal pain between January 1, 2003, and December 31, 2007. Individuals who were newly dispensed tramadol (N = 41,963) were identified and propensity score–matched with those who were not (N = 41,963). Over a maximum of 14-year follow-up, the incidence rates (events per 1000 person-years) of all-cause dementia were 6.1 for nonusers, 6.2 for those with cumulative tramadol use of 1–14 days, 7.7 for those with 15–90 days of use, and 8.0 for those with > 90 days of use. Longer cumulative duration of tramadol use was associated with an increased risk of all-cause dementia compared with nonuse (1 to 14 days: aHR 1.06, 95% CI 0.96–1.17; 15 to 90 days: aHR 1.14, 95% CI 1.10–1.35; and more than 90 days: aHR 1.18, 95% CI 1.00–1.39; test for trend: P < 0.001). The results showed a similar pattern for Alzheimer’s disease and were robust across subgroup and sensitivity analyses, but not for vascular dementia. This study found that exposure to tramadol was associated with an increased risk of dementia. Taking this potential risk into consideration, clinicians should carefully weigh potential benefits and risks when prescribing tramadol to older adults with musculoskeletal pain.https://doi.org/10.1038/s41598-024-74817-3TramadolDementiaAlzheimer’s diseaseVascular dementiaPain |
| spellingShingle | Si Nae Oh Hye Jun Kim Jae Yong Shim Kyuwoong Kim Seogsong Jeong Sun Jae Park Sang Hyun Lee Joong Won Ha Sang Min Park Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study Scientific Reports Tramadol Dementia Alzheimer’s disease Vascular dementia Pain |
| title | Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study |
| title_full | Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study |
| title_fullStr | Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study |
| title_full_unstemmed | Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study |
| title_short | Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study |
| title_sort | tramadol use and incident dementia in older adults with musculoskeletal pain a population based retrospective cohort study |
| topic | Tramadol Dementia Alzheimer’s disease Vascular dementia Pain |
| url | https://doi.org/10.1038/s41598-024-74817-3 |
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