Bleeding due to a Broken Heart Valve: Heyde’s Syndrome Secondary to Severe Mitral Regurgitation
Heyde’s syndrome (HS) is classically characterized by the unique relationship between severe aortic stenosis and gastrointestinal bleeding (GIB) from angiodysplasia. Specifically, the shear stress from valvular disease results in acquired von Willebrand syndrome due to destruction of high-molecular-...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Gastro Hep Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572325000366 |
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| author | Bibek Saha Jenny J. Cao Kayla Finnegan Darine Daher Allison Reinhardt Bright Thilagar |
| author_facet | Bibek Saha Jenny J. Cao Kayla Finnegan Darine Daher Allison Reinhardt Bright Thilagar |
| author_sort | Bibek Saha |
| collection | DOAJ |
| description | Heyde’s syndrome (HS) is classically characterized by the unique relationship between severe aortic stenosis and gastrointestinal bleeding (GIB) from angiodysplasia. Specifically, the shear stress from valvular disease results in acquired von Willebrand syndrome due to destruction of high-molecular-weight multimers. We present a rare case of HS resulting from severe mitral regurgitation (MR). A 75-year-old male with severe MR was hospitalized twice in a 4-month period for GIB from duodenal angiodysplasia. He was found to have acquired von Willebrand syndrome and managed endoscopically. HS should be in the differential diagnosis for recurrent GIB, especially in the setting of concomitant severe MR. |
| format | Article |
| id | doaj-art-620f6cd9ecb7472ebe2f948dc4e46c33 |
| institution | Kabale University |
| issn | 2772-5723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj-art-620f6cd9ecb7472ebe2f948dc4e46c332025-08-20T03:29:31ZengElsevierGastro Hep Advances2772-57232025-01-014610064910.1016/j.gastha.2025.100649Bleeding due to a Broken Heart Valve: Heyde’s Syndrome Secondary to Severe Mitral RegurgitationBibek Saha0Jenny J. Cao1Kayla Finnegan2Darine Daher3Allison Reinhardt4Bright Thilagar5Department of Internal Medicine, Mayo Clinic, Rochester, MinnesotaDepartment of Internal Medicine, Mayo Clinic, Rochester, MinnesotaDepartment of Internal Medicine, Mayo Clinic, Rochester, MinnesotaDepartment of Internal Medicine, Mayo Clinic, Rochester, MinnesotaDepartment of Internal Medicine, Mayo Clinic, Rochester, MinnesotaDivision of General Internal Medicine, Mayo Clinic, Rochester, Minnesota; Correspondence: Address correspondence to: Bright Thilagar, MD, Division of General Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, Minnesota 55905.Heyde’s syndrome (HS) is classically characterized by the unique relationship between severe aortic stenosis and gastrointestinal bleeding (GIB) from angiodysplasia. Specifically, the shear stress from valvular disease results in acquired von Willebrand syndrome due to destruction of high-molecular-weight multimers. We present a rare case of HS resulting from severe mitral regurgitation (MR). A 75-year-old male with severe MR was hospitalized twice in a 4-month period for GIB from duodenal angiodysplasia. He was found to have acquired von Willebrand syndrome and managed endoscopically. HS should be in the differential diagnosis for recurrent GIB, especially in the setting of concomitant severe MR.http://www.sciencedirect.com/science/article/pii/S2772572325000366Mitral ValveAngiodysplasiaAcquired von Willebrand SyndromeGastrointestinal Bleeding |
| spellingShingle | Bibek Saha Jenny J. Cao Kayla Finnegan Darine Daher Allison Reinhardt Bright Thilagar Bleeding due to a Broken Heart Valve: Heyde’s Syndrome Secondary to Severe Mitral Regurgitation Gastro Hep Advances Mitral Valve Angiodysplasia Acquired von Willebrand Syndrome Gastrointestinal Bleeding |
| title | Bleeding due to a Broken Heart Valve: Heyde’s Syndrome Secondary to Severe Mitral Regurgitation |
| title_full | Bleeding due to a Broken Heart Valve: Heyde’s Syndrome Secondary to Severe Mitral Regurgitation |
| title_fullStr | Bleeding due to a Broken Heart Valve: Heyde’s Syndrome Secondary to Severe Mitral Regurgitation |
| title_full_unstemmed | Bleeding due to a Broken Heart Valve: Heyde’s Syndrome Secondary to Severe Mitral Regurgitation |
| title_short | Bleeding due to a Broken Heart Valve: Heyde’s Syndrome Secondary to Severe Mitral Regurgitation |
| title_sort | bleeding due to a broken heart valve heyde s syndrome secondary to severe mitral regurgitation |
| topic | Mitral Valve Angiodysplasia Acquired von Willebrand Syndrome Gastrointestinal Bleeding |
| url | http://www.sciencedirect.com/science/article/pii/S2772572325000366 |
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