Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by excessive inflammatory and immune responses and tissue damage. Increasing evidence has demonstrated the important role of programmed cell death in SLE pathogenesis. When apoptosis encounters with defective clea...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/3638562 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564537057869824 |
|---|---|
| author | Fangyuan Yang Yi He Zeqing Zhai Erwei Sun |
| author_facet | Fangyuan Yang Yi He Zeqing Zhai Erwei Sun |
| author_sort | Fangyuan Yang |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by excessive inflammatory and immune responses and tissue damage. Increasing evidence has demonstrated the important role of programmed cell death in SLE pathogenesis. When apoptosis encounters with defective clearance, accumulated apoptotic cells lead to secondary necrosis. Different forms of lytic cell death, including secondary necrosis after apoptosis, NETosis, necroptosis, and pyroptosis, contribute to the release of damage-associated molecular patterns (DAMPs) and autoantigens, resulting in triggering immunity and tissue damage in SLE. However, the role of autophagy in SLE pathogenesis is in dispute. This review briefly discusses different forms of programmed cell death pathways and lay particular emphasis on inflammatory cell death pathways such as NETosis, pyroptosis, and necroptosis and their roles in the inflammatory and immune responses in SLE. |
| format | Article |
| id | doaj-art-61dd809e1d174584b5e4060adc91ed41 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-61dd809e1d174584b5e4060adc91ed412025-02-03T01:10:49ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/36385623638562Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus ErythematosusFangyuan Yang0Yi He1Zeqing Zhai2Erwei Sun3Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, ChinaSystemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by excessive inflammatory and immune responses and tissue damage. Increasing evidence has demonstrated the important role of programmed cell death in SLE pathogenesis. When apoptosis encounters with defective clearance, accumulated apoptotic cells lead to secondary necrosis. Different forms of lytic cell death, including secondary necrosis after apoptosis, NETosis, necroptosis, and pyroptosis, contribute to the release of damage-associated molecular patterns (DAMPs) and autoantigens, resulting in triggering immunity and tissue damage in SLE. However, the role of autophagy in SLE pathogenesis is in dispute. This review briefly discusses different forms of programmed cell death pathways and lay particular emphasis on inflammatory cell death pathways such as NETosis, pyroptosis, and necroptosis and their roles in the inflammatory and immune responses in SLE.http://dx.doi.org/10.1155/2019/3638562 |
| spellingShingle | Fangyuan Yang Yi He Zeqing Zhai Erwei Sun Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus Journal of Immunology Research |
| title | Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus |
| title_full | Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus |
| title_fullStr | Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus |
| title_full_unstemmed | Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus |
| title_short | Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus |
| title_sort | programmed cell death pathways in the pathogenesis of systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2019/3638562 |
| work_keys_str_mv | AT fangyuanyang programmedcelldeathpathwaysinthepathogenesisofsystemiclupuserythematosus AT yihe programmedcelldeathpathwaysinthepathogenesisofsystemiclupuserythematosus AT zeqingzhai programmedcelldeathpathwaysinthepathogenesisofsystemiclupuserythematosus AT erweisun programmedcelldeathpathwaysinthepathogenesisofsystemiclupuserythematosus |