Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff
Background. For the treatment of visceral leishmaniasis in Bangladesh, single dose liposomal amphotericin B (ambisome) is supposed to be the safest and most effective treatment. Specific needs for application and storage raise questions about feasibility of its implementation and acceptance by patie...
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| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/676817 |
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| author | Eva-Maria Maintz Mahbub Hassan M. Mamun Huda Debashis Ghosh Md. Shakhawat Hossain Abdul Alim Axel Kroeger Byron Arana Dinesh Mondal |
| author_facet | Eva-Maria Maintz Mahbub Hassan M. Mamun Huda Debashis Ghosh Md. Shakhawat Hossain Abdul Alim Axel Kroeger Byron Arana Dinesh Mondal |
| author_sort | Eva-Maria Maintz |
| collection | DOAJ |
| description | Background. For the treatment of visceral leishmaniasis in Bangladesh, single dose liposomal amphotericin B (ambisome) is supposed to be the safest and most effective treatment. Specific needs for application and storage raise questions about feasibility of its implementation and acceptance by patients and health staff. Methods. The study was carried out in the most endemic district of Bangladesh. Study population includes patients treated with ambisome or miltefosine, hospital staff, and a director of the national visceral leishmaniasis program. Study methods include direct observation (subdistrict hospitals), open interviews (heath staff and program personnel), structured questionnaires, and focus group discussions (patients). Results. Politicalcommitment for ambisome is strong; the general hospital infrastructure favours implementation but further strengthening is required, particularly for drug storage below 25°C (refrigerators), back-up energy (fuel for generators), and supplies for ambisome administration (like 5% dextrose solution). Ambisome created high satisfaction in patients and hospital staff, less adverse events, and less income loss for patients compared to miltefosine. Conclusions. High political commitment, general capacities of subdistrict hospitals, and high acceptability favour the implementation of ambisome treatment in Bangladesh. However, strengthening of the infrastructure and uninterrupted supplies of essential accessories is mandatory before introducing sLAB in Bangladesh. |
| format | Article |
| id | doaj-art-61d8745d0cf643b0912136a54d662188 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-61d8745d0cf643b0912136a54d6621882025-02-03T05:53:59ZengWileyJournal of Tropical Medicine1687-96861687-96942014-01-01201410.1155/2014/676817676817Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health StaffEva-Maria Maintz0Mahbub Hassan1M. Mamun Huda2Debashis Ghosh3Md. Shakhawat Hossain4Abdul Alim5Axel Kroeger6Byron Arana7Dinesh Mondal8Faculty of Medicine, Albert Ludwigs University, 79085 Freiburg, GermanyInternational Centre for Diarrhoeal Diseases Research, Bangladesh (ICDDR,B), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Diseases Research, Bangladesh (ICDDR,B), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Diseases Research, Bangladesh (ICDDR,B), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Diseases Research, Bangladesh (ICDDR,B), Dhaka 1212, BangladeshInternational Centre for Diarrhoeal Diseases Research, Bangladesh (ICDDR,B), Dhaka 1212, BangladeshLiverpool School of Tropical Medicine, Liverpool L3 5QA, UKSpecial Programme for Research and Training in Tropical Diseases (TDR-WHO), 1211 Geneva, SwitzerlandInternational Centre for Diarrhoeal Diseases Research, Bangladesh (ICDDR,B), Dhaka 1212, BangladeshBackground. For the treatment of visceral leishmaniasis in Bangladesh, single dose liposomal amphotericin B (ambisome) is supposed to be the safest and most effective treatment. Specific needs for application and storage raise questions about feasibility of its implementation and acceptance by patients and health staff. Methods. The study was carried out in the most endemic district of Bangladesh. Study population includes patients treated with ambisome or miltefosine, hospital staff, and a director of the national visceral leishmaniasis program. Study methods include direct observation (subdistrict hospitals), open interviews (heath staff and program personnel), structured questionnaires, and focus group discussions (patients). Results. Politicalcommitment for ambisome is strong; the general hospital infrastructure favours implementation but further strengthening is required, particularly for drug storage below 25°C (refrigerators), back-up energy (fuel for generators), and supplies for ambisome administration (like 5% dextrose solution). Ambisome created high satisfaction in patients and hospital staff, less adverse events, and less income loss for patients compared to miltefosine. Conclusions. High political commitment, general capacities of subdistrict hospitals, and high acceptability favour the implementation of ambisome treatment in Bangladesh. However, strengthening of the infrastructure and uninterrupted supplies of essential accessories is mandatory before introducing sLAB in Bangladesh.http://dx.doi.org/10.1155/2014/676817 |
| spellingShingle | Eva-Maria Maintz Mahbub Hassan M. Mamun Huda Debashis Ghosh Md. Shakhawat Hossain Abdul Alim Axel Kroeger Byron Arana Dinesh Mondal Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff Journal of Tropical Medicine |
| title | Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff |
| title_full | Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff |
| title_fullStr | Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff |
| title_full_unstemmed | Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff |
| title_short | Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff |
| title_sort | introducing single dose liposomal amphotericin b for the treatment of visceral leishmaniasis in rural bangladesh feasibility and acceptance to patients and health staff |
| url | http://dx.doi.org/10.1155/2014/676817 |
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