Neutrophil-to-lymphocyte ratio: A biomarker for predicting systemic involvement in iga vasculitis
Context:“IgA vasculitis, is an immune complex mediated, self limited cutaneous small vessel vasculitis, characterized by palpable purpurae, arthralgia or arthritis, gastrointestinal and/or renal involvement.” Systemic involvement is considered to be the presence of gastrointestinal (GI) and/or renal...
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SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=3;spage=187;epage=191;aulast=George |
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| _version_ | 1832569120427606016 |
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| author | Rintu Merin George Arun C Inamadar Ajit B Janagond |
| author_facet | Rintu Merin George Arun C Inamadar Ajit B Janagond |
| author_sort | Rintu Merin George |
| collection | DOAJ |
| description | Context:“IgA vasculitis, is an immune complex mediated, self limited cutaneous small vessel vasculitis, characterized by palpable purpurae, arthralgia or arthritis, gastrointestinal and/or renal involvement.” Systemic involvement is considered to be the presence of gastrointestinal (GI) and/or renal involvement in IgA vasculitis patients. Neutrophil-to-lymphocyte ratio (NLR) is a relatively cost-effective and easily obtainable laboratory parameter integrating information on two immune pathways to provide a superior predictive ability over other inflammatory parameters regarding systemic involvement.
Aims: The aim of the study was to assess the predictive value of NLR with regard to the systemic involvement in IgA vasculitis.
Subjects and Methods: This was a hospital-based cross-sectional study of patients diagnosed with IgA vasculitis, irrespective of age, between 2017 and 2019.
Results: The study consisted of 33 patients with a mean age of 33.52 ± 19.78 years. Joint involvement was observed in 52% (17), whereas systemic manifestations in the form of renal involvement were present in 7 (21%), GI in 19 (57.6%), and renal and/or GI in 22 (66.7%) patients. NLR was found to be significantly associated with GI manifestations (P < 0.001). Optimal cutoff value of NLR for predicting systemic involvement was 3.25, with a specificity of 100% and sensitivity of 59%.
Conclusions: NLR can be considered as a biomarker for predicting systemic involvement in IgA vasculitis, presenting with only cutaneous with/without joint manifestations. |
| format | Article |
| id | doaj-art-61d6987f6d29426d9079cb9837ac2f33 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-61d6987f6d29426d9079cb9837ac2f332025-02-02T23:15:33ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012020-01-0115318719110.4103/injr.injr_166_19Neutrophil-to-lymphocyte ratio: A biomarker for predicting systemic involvement in iga vasculitisRintu Merin GeorgeArun C InamadarAjit B JanagondContext:“IgA vasculitis, is an immune complex mediated, self limited cutaneous small vessel vasculitis, characterized by palpable purpurae, arthralgia or arthritis, gastrointestinal and/or renal involvement.” Systemic involvement is considered to be the presence of gastrointestinal (GI) and/or renal involvement in IgA vasculitis patients. Neutrophil-to-lymphocyte ratio (NLR) is a relatively cost-effective and easily obtainable laboratory parameter integrating information on two immune pathways to provide a superior predictive ability over other inflammatory parameters regarding systemic involvement. Aims: The aim of the study was to assess the predictive value of NLR with regard to the systemic involvement in IgA vasculitis. Subjects and Methods: This was a hospital-based cross-sectional study of patients diagnosed with IgA vasculitis, irrespective of age, between 2017 and 2019. Results: The study consisted of 33 patients with a mean age of 33.52 ± 19.78 years. Joint involvement was observed in 52% (17), whereas systemic manifestations in the form of renal involvement were present in 7 (21%), GI in 19 (57.6%), and renal and/or GI in 22 (66.7%) patients. NLR was found to be significantly associated with GI manifestations (P < 0.001). Optimal cutoff value of NLR for predicting systemic involvement was 3.25, with a specificity of 100% and sensitivity of 59%. Conclusions: NLR can be considered as a biomarker for predicting systemic involvement in IgA vasculitis, presenting with only cutaneous with/without joint manifestations.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=3;spage=187;epage=191;aulast=Georgearthralgiagastrointestinal involvementhenoch–schonlein purpurarenal involvement |
| spellingShingle | Rintu Merin George Arun C Inamadar Ajit B Janagond Neutrophil-to-lymphocyte ratio: A biomarker for predicting systemic involvement in iga vasculitis Indian Journal of Rheumatology arthralgia gastrointestinal involvement henoch–schonlein purpura renal involvement |
| title | Neutrophil-to-lymphocyte ratio: A biomarker for predicting systemic involvement in iga vasculitis |
| title_full | Neutrophil-to-lymphocyte ratio: A biomarker for predicting systemic involvement in iga vasculitis |
| title_fullStr | Neutrophil-to-lymphocyte ratio: A biomarker for predicting systemic involvement in iga vasculitis |
| title_full_unstemmed | Neutrophil-to-lymphocyte ratio: A biomarker for predicting systemic involvement in iga vasculitis |
| title_short | Neutrophil-to-lymphocyte ratio: A biomarker for predicting systemic involvement in iga vasculitis |
| title_sort | neutrophil to lymphocyte ratio a biomarker for predicting systemic involvement in iga vasculitis |
| topic | arthralgia gastrointestinal involvement henoch–schonlein purpura renal involvement |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=3;spage=187;epage=191;aulast=George |
| work_keys_str_mv | AT rintumeringeorge neutrophiltolymphocyteratioabiomarkerforpredictingsystemicinvolvementinigavasculitis AT aruncinamadar neutrophiltolymphocyteratioabiomarkerforpredictingsystemicinvolvementinigavasculitis AT ajitbjanagond neutrophiltolymphocyteratioabiomarkerforpredictingsystemicinvolvementinigavasculitis |