Prevalence of antimalaria drug resistance-conferring mutations associated with sulphadoxine-pyrimethamineine-resistant Plasmodium falciparum in East Africa: a systematic review and meta-analysis

Prevalence of antimalaria drug resistance-conferring mutations associated with sulphadoxine-pyrimethamineine-resistant Plasmodium falciparum in East Africa: a systematic review and meta-analysis

Abstract Background The emergence and spread of drug resistance to antimalarial drugs pose a severe threat to effective malaria control and treatment. Although sulfadoxine-pyrimethamine resistance is well-documented, it is still the drug of choice for treating intermittent resistance. Molecular mark...

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Main Authors: Wagaw Abebe, Agenagnew Ashagre, Tadesse Misganaw, Zelalem Dejazmach, Getinet Kumie, Marye Nigatie, Abdu Jemal, Zelalem Asmare, Woldeteklehaymanot Kassahun, Solomon Gedfie, Ermias Getachew, Muluken Gashaw, Sisay Ayana, Yalewayker Gashaw, Assefa Sisay, Selamyhun Tadesse, Tegegne Eshetu, Mulat awoke, Birhanu Kassanew, Atitegeb Abera Kidie, Biruk Beletew Abate, Melese Abate Reta
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Annals of Clinical Microbiology and Antimicrobials
Subjects:
Prevalence
Plasmodium falciparum
Drug resistance
Marker
Sulphadoxine-pyrimethamineine
East Africa
Online Access:https://doi.org/10.1186/s12941-025-00795-7
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https://doi.org/10.1186/s12941-025-00795-7

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