Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects
Background. It has been suggested that the angiotensinogen (AGT) gene rs4762 (p.Thr174Met) polymorphism might be associated with myocardial infarction (MI) risk, but the study results are still debatable. Objective and Methods. In order to explore the relationship between AGT p.Thr174Met polymorphis...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2021/6667934 |
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| _version_ | 1832564477646602240 |
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| author | Yan-yan Li Hui Wang Hao Wang Yang-yang Zhang |
| author_facet | Yan-yan Li Hui Wang Hao Wang Yang-yang Zhang |
| author_sort | Yan-yan Li |
| collection | DOAJ |
| description | Background. It has been suggested that the angiotensinogen (AGT) gene rs4762 (p.Thr174Met) polymorphism might be associated with myocardial infarction (MI) risk, but the study results are still debatable. Objective and Methods. In order to explore the relationship between AGT p.Thr174Met polymorphism and MI risk, the current meta-analysis involving 7657 subjects from 11 individual studies was conducted. Results. A significant association between AGT p.Thr174Met polymorphism and MI was found under recessive (OR: 2.26, 95% CI: 1.35-3.77, P=0.002), dominant (OR: 1.131, 95% CI: 1.016-1.260, P=0.024), codominant (OR: 2.198, 95% CI: 1.334-3.621, P=0.002), and additive (OR: 1.363, 95% CI: 1.132-1.641, P=0.001) genetic models. In the Asian subgroup, significantly increased MI risk was found under all genetic models (P<0.05). No significant association between AGT p.Thr174Met polymorphism and MI was found under all genetic models in the Caucasian subgroup (P>0.05). Conclusions. AGT p.Thr174Met variant might increase MI risk, especially within the Asian population. The Met174 allele of AGT p.Thr174Met might confer the risk for MI. |
| format | Article |
| id | doaj-art-61b3b63a6ca247afa021e642a9fdd27c |
| institution | Kabale University |
| issn | 1755-5914 1755-5922 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-61b3b63a6ca247afa021e642a9fdd27c2025-02-03T01:10:54ZengWileyCardiovascular Therapeutics1755-59141755-59222021-01-01202110.1155/2021/66679346667934Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 SubjectsYan-yan Li0Hui Wang1Hao Wang2Yang-yang Zhang3Clinical Research Center, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of General Practice, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaBackground. It has been suggested that the angiotensinogen (AGT) gene rs4762 (p.Thr174Met) polymorphism might be associated with myocardial infarction (MI) risk, but the study results are still debatable. Objective and Methods. In order to explore the relationship between AGT p.Thr174Met polymorphism and MI risk, the current meta-analysis involving 7657 subjects from 11 individual studies was conducted. Results. A significant association between AGT p.Thr174Met polymorphism and MI was found under recessive (OR: 2.26, 95% CI: 1.35-3.77, P=0.002), dominant (OR: 1.131, 95% CI: 1.016-1.260, P=0.024), codominant (OR: 2.198, 95% CI: 1.334-3.621, P=0.002), and additive (OR: 1.363, 95% CI: 1.132-1.641, P=0.001) genetic models. In the Asian subgroup, significantly increased MI risk was found under all genetic models (P<0.05). No significant association between AGT p.Thr174Met polymorphism and MI was found under all genetic models in the Caucasian subgroup (P>0.05). Conclusions. AGT p.Thr174Met variant might increase MI risk, especially within the Asian population. The Met174 allele of AGT p.Thr174Met might confer the risk for MI.http://dx.doi.org/10.1155/2021/6667934 |
| spellingShingle | Yan-yan Li Hui Wang Hao Wang Yang-yang Zhang Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects Cardiovascular Therapeutics |
| title | Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects |
| title_full | Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects |
| title_fullStr | Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects |
| title_full_unstemmed | Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects |
| title_short | Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects |
| title_sort | myocardial infarction and agt p thr174met polymorphism a meta analysis of 7657 subjects |
| url | http://dx.doi.org/10.1155/2021/6667934 |
| work_keys_str_mv | AT yanyanli myocardialinfarctionandagtpthr174metpolymorphismametaanalysisof7657subjects AT huiwang myocardialinfarctionandagtpthr174metpolymorphismametaanalysisof7657subjects AT haowang myocardialinfarctionandagtpthr174metpolymorphismametaanalysisof7657subjects AT yangyangzhang myocardialinfarctionandagtpthr174metpolymorphismametaanalysisof7657subjects |