Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult
A 54-year-old white female with hypothyroidism presented with abdominal pain, nausea, vomiting, and diarrhea. She was found to have diabetic ketoacidosis (DKA) and admitted to our hospital for treatment. Laboratory workup revealed positive antiglutamic acid decarboxylase antibodies and subsequently...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/821397 |
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| author | Omar Nadhem Essam Nakhla Roger D. Smalligan |
| author_facet | Omar Nadhem Essam Nakhla Roger D. Smalligan |
| author_sort | Omar Nadhem |
| collection | DOAJ |
| description | A 54-year-old white female with hypothyroidism presented with abdominal pain, nausea, vomiting, and diarrhea. She was found to have diabetic ketoacidosis (DKA) and admitted to our hospital for treatment. Laboratory workup revealed positive antiglutamic acid decarboxylase antibodies and subsequently she was diagnosed with latent onset autoimmune diabetes in adult (LADA). She was successfully treated with insulin with clinical and laboratory improvement. Diagnosis of LADA has been based on three criteria as given by The Immunology of Diabetes Society: (1) adult age of onset (>30 years of age); (2) presence of at least one circulating autoantibody (GADA/ICA/IAA/IA-2); and (3) initial insulin independence for the first six months. The importance of this case is the unlikely presentation of LADA. We believe that more research is needed to determine the exact proportion of LADA patients who first present with DKA, since similar cases have only been seen in case reports. Adult patients who are obese and have high blood sugar may deserve screening for LADA, especially in the presence of other autoimmune diseases. Those patients once diagnosed with LADA need extensive diabetic education including potentially serious events such as diabetic ketoacidosis. |
| format | Article |
| id | doaj-art-618dfd369cad4d89b6487f168e4a531a |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-618dfd369cad4d89b6487f168e4a531a2025-02-03T06:11:39ZengWileyCase Reports in Medicine1687-96271687-96352015-01-01201510.1155/2015/821397821397Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in AdultOmar Nadhem0Essam Nakhla1Roger D. Smalligan2Internal Medicine Department, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USAInternal Medicine Department, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USAInternal Medicine Department, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USAA 54-year-old white female with hypothyroidism presented with abdominal pain, nausea, vomiting, and diarrhea. She was found to have diabetic ketoacidosis (DKA) and admitted to our hospital for treatment. Laboratory workup revealed positive antiglutamic acid decarboxylase antibodies and subsequently she was diagnosed with latent onset autoimmune diabetes in adult (LADA). She was successfully treated with insulin with clinical and laboratory improvement. Diagnosis of LADA has been based on three criteria as given by The Immunology of Diabetes Society: (1) adult age of onset (>30 years of age); (2) presence of at least one circulating autoantibody (GADA/ICA/IAA/IA-2); and (3) initial insulin independence for the first six months. The importance of this case is the unlikely presentation of LADA. We believe that more research is needed to determine the exact proportion of LADA patients who first present with DKA, since similar cases have only been seen in case reports. Adult patients who are obese and have high blood sugar may deserve screening for LADA, especially in the presence of other autoimmune diseases. Those patients once diagnosed with LADA need extensive diabetic education including potentially serious events such as diabetic ketoacidosis.http://dx.doi.org/10.1155/2015/821397 |
| spellingShingle | Omar Nadhem Essam Nakhla Roger D. Smalligan Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult Case Reports in Medicine |
| title | Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult |
| title_full | Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult |
| title_fullStr | Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult |
| title_full_unstemmed | Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult |
| title_short | Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult |
| title_sort | diabetic ketoacidosis as first presentation of latent autoimmune diabetes in adult |
| url | http://dx.doi.org/10.1155/2015/821397 |
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