转化生长因子β1和上皮细胞间充质转分化在糖尿病肾脏疾病中的作用
<正>在美国糖尿病肾脏疾病（diabetic kidney disease,DKD）的发病率在近十年内升高近2倍,有近50%的患者走向终末期肾脏疾病（end stage renal disease,ESRD）。DKD已经成为导致患者肾脏代替治疗的常见肾脏病之一<sup>[1]</sup>。高血糖引起的结构损伤包括基底膜肥厚、肾小管萎缩及肾间质纤维化,这些改变导致了肾小球滤过率增加、蛋白尿、高血压及肾功能的减退<sup>[2]</sup>。在组织学上,糖尿病患者肾小球系膜和肾间质细胞外基质（extracellular matrix,EC...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57920344&Fpath=home&index=0 |
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