The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise Testing
<b>Background/Objectives</b>: Heart failure (HF) constitutes a complex clinical syndrome that is highly prevalent worldwide, comprises a serious prognosis, and results in a reduced quality of life. Exercise capacity is one of the most significant parameters involved in the prognosis in H...
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2024-12-01
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| author | Magdalena Dudek Marta Kałużna-Oleksy Filip Sawczak Agata Kukfisz Aleksandra Soloch Jacek Migaj Maciej Lesiak Ewa Straburzyńska-Migaj |
| author_facet | Magdalena Dudek Marta Kałużna-Oleksy Filip Sawczak Agata Kukfisz Aleksandra Soloch Jacek Migaj Maciej Lesiak Ewa Straburzyńska-Migaj |
| author_sort | Magdalena Dudek |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Heart failure (HF) constitutes a complex clinical syndrome that is highly prevalent worldwide, comprises a serious prognosis, and results in a reduced quality of life. Exercise capacity is one of the most significant parameters involved in the prognosis in HF patients. Our objective was to evaluate the relationship between the selected cardiopulmonary exercise testing (CPET) parameters and the concentration of novel biomarker sST2 in a group of patients with heart failure with reduced ejection fraction (HFrEF). <b>Methods</b>: A group of 135 patients with HFrEF was enrolled in this prospective cohort study. Patients were in the stable phase of the disease in the prior 4 weeks and received optimal medical treatment. Clinical and biochemical parameters were investigated. All patients performed maximal CPET. <b>Results</b>: The mean (SD) concentration of sST2 was 45.5 ± 39.2 ng/mL. Based on the CPET results, the cut-off value (52.377 ng/mL) was established, optimal for the discrimination of relative peakVO<sub>2</sub> < 12 mL/kg/min. Patients were divided into two groups according to sST2 cut-off values determined with an ROC curve (AUC 0.692, 95% CI: 0.567–0.816). The mean relative peakVO<sub>2</sub> in patients with higher sST2 was 14.5 ± 4.6 mL/kg/min, while in the second group, it was 17.6 ± 5.2 (<i>p</i> = 0.002). In the sST2 ≥ 52.377 ng/mL group, 55.6% of patients achieved VO<sub>2</sub> < 50%. Subjects with lower sST2 values obtained higher values of PETCO<sub>2</sub> (<i>p</i> < 0.001) and higher values of pulse O<sub>2</sub> (<i>p</i> = 0.01). VE/VCO<sub>2</sub>slope (<i>p</i> = 0.002) was higher in patients with increased sST2 concentration. <b>Conclusions</b>: The concentration of sST2 protein is substantially associated with the clinical severity of heart failure with reduced left ventricular ejection fraction assessed by functional capacity through CPET. |
| format | Article |
| id | doaj-art-6167856dbd5d4941baaabf4488f2ed58 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-6167856dbd5d4941baaabf4488f2ed582025-01-24T13:23:52ZengMDPI AGBiomedicines2227-90592024-12-011316010.3390/biomedicines13010060The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise TestingMagdalena Dudek0Marta Kałużna-Oleksy1Filip Sawczak2Agata Kukfisz3Aleksandra Soloch4Jacek Migaj5Maciej Lesiak6Ewa Straburzyńska-Migaj71st Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznań, Poland1st Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznań, Poland1st Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznań, Poland3rd Department of Cardiology, Silesian Center for Heart Disease, Faculty of Medical University of Silesia, 41-800 Zabrze, Poland1st Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznań, Poland1st Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznań, Poland1st Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznań, Poland1st Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznań, Poland<b>Background/Objectives</b>: Heart failure (HF) constitutes a complex clinical syndrome that is highly prevalent worldwide, comprises a serious prognosis, and results in a reduced quality of life. Exercise capacity is one of the most significant parameters involved in the prognosis in HF patients. Our objective was to evaluate the relationship between the selected cardiopulmonary exercise testing (CPET) parameters and the concentration of novel biomarker sST2 in a group of patients with heart failure with reduced ejection fraction (HFrEF). <b>Methods</b>: A group of 135 patients with HFrEF was enrolled in this prospective cohort study. Patients were in the stable phase of the disease in the prior 4 weeks and received optimal medical treatment. Clinical and biochemical parameters were investigated. All patients performed maximal CPET. <b>Results</b>: The mean (SD) concentration of sST2 was 45.5 ± 39.2 ng/mL. Based on the CPET results, the cut-off value (52.377 ng/mL) was established, optimal for the discrimination of relative peakVO<sub>2</sub> < 12 mL/kg/min. Patients were divided into two groups according to sST2 cut-off values determined with an ROC curve (AUC 0.692, 95% CI: 0.567–0.816). The mean relative peakVO<sub>2</sub> in patients with higher sST2 was 14.5 ± 4.6 mL/kg/min, while in the second group, it was 17.6 ± 5.2 (<i>p</i> = 0.002). In the sST2 ≥ 52.377 ng/mL group, 55.6% of patients achieved VO<sub>2</sub> < 50%. Subjects with lower sST2 values obtained higher values of PETCO<sub>2</sub> (<i>p</i> < 0.001) and higher values of pulse O<sub>2</sub> (<i>p</i> = 0.01). VE/VCO<sub>2</sub>slope (<i>p</i> = 0.002) was higher in patients with increased sST2 concentration. <b>Conclusions</b>: The concentration of sST2 protein is substantially associated with the clinical severity of heart failure with reduced left ventricular ejection fraction assessed by functional capacity through CPET.https://www.mdpi.com/2227-9059/13/1/60ST2sST2biomarkercardiopulmonary exercise testingCPETheart failure |
| spellingShingle | Magdalena Dudek Marta Kałużna-Oleksy Filip Sawczak Agata Kukfisz Aleksandra Soloch Jacek Migaj Maciej Lesiak Ewa Straburzyńska-Migaj The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise Testing Biomedicines ST2 sST2 biomarker cardiopulmonary exercise testing CPET heart failure |
| title | The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise Testing |
| title_full | The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise Testing |
| title_fullStr | The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise Testing |
| title_full_unstemmed | The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise Testing |
| title_short | The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise Testing |
| title_sort | usefulness of soluble st2 concentration in heart failure with reduced ejection fraction to predict severe impairment in exercise capacity assessed in cardiopulmonary exercise testing |
| topic | ST2 sST2 biomarker cardiopulmonary exercise testing CPET heart failure |
| url | https://www.mdpi.com/2227-9059/13/1/60 |
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