Epigallocatechin gallate, the primary bioactive component from Camellia sinensis: A review on immunomodulatory effects in autoimmune diseases by balancing the differentiation of Th and Treg cells
Autoimmune disease is a chronic condition that requires treatment with prolonged use of drugs. Consequently, there is a significant occurrence of adverse effects and toxicity associated with the medicine. On the other hand, epigallocatechin gallate (EGCG), the primary bioactive catechin in green tea...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahrekord University of Medical Sciences
2024-04-01
|
| Series: | Journal of HerbMed Pharmacology |
| Subjects: | |
| Online Access: | https://herbmedpharmacol.com/PDF/jhp-13-176.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850057011860865024 |
|---|---|
| author | Vigha Ilmanafi Arifka Andayana Puspitasari Gani Retno Murwanti |
| author_facet | Vigha Ilmanafi Arifka Andayana Puspitasari Gani Retno Murwanti |
| author_sort | Vigha Ilmanafi Arifka |
| collection | DOAJ |
| description | Autoimmune disease is a chronic condition that requires treatment with prolonged use of drugs. Consequently, there is a significant occurrence of adverse effects and toxicity associated with the medicine. On the other hand, epigallocatechin gallate (EGCG), the primary bioactive catechin in green tea (Camellia sinensis), has been demonstrated to possess anti-inflammatory properties and exhibit therapeutic effects in autoimmune disorders. Therefore, EGCG can be considered a complementary and alternative medicine to address the limitations of current treatment. Turning to the disease pathology, the balance between helper T-cell (Th) and regulatory T-cell (Treg) differentiation is the crucial aspect that needs to be regulated in order to attain immunological tolerance and suppress the incidence and severity of autoimmune disease. Here, we aim to comprehensively review the immunomodulatory effect of EGCG on the balance of Th/Treg cell differentiation in diverse autoimmune disorders. Scientific databases, including Scopus, PubMed, Science Direct, and Google Scholar, were searched using the keywords autoimmune AND (epigallocatechin-3-gallate OR epigallocatechin gallate OR EGCG) AND (Thelper OR Th OR Treg OR CD4). Our review revealed that EGCG has ability to repair the imbalance of Th/Treg cell differentiation in rheumatoid arthritis (RA), multiple sclerosis (MS), ulcerative colitis (UC), and autoimmune uveitis (AU) by inhibiting the differentiation of Th1 and Th17 cells while promoting the differentiation of Th2 and Treg cells, as well as improving the clinical conditions of the tested animals. Hence, it might be inferred that EGCG exhibits considerable promise as a viable complementary and alternative therapeutic option for autoimmune disease. |
| format | Article |
| id | doaj-art-6166fc52dcb74a528a0ee7c6cfe01367 |
| institution | DOAJ |
| issn | 2345-5004 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj-art-6166fc52dcb74a528a0ee7c6cfe013672025-08-20T02:51:32ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042024-04-0113217618710.34172/jhp.2024.48284jhp-48284Epigallocatechin gallate, the primary bioactive component from Camellia sinensis: A review on immunomodulatory effects in autoimmune diseases by balancing the differentiation of Th and Treg cellsVigha Ilmanafi Arifka0Andayana Puspitasari Gani1Retno Murwanti2Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, IndonesiaDepartement of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, IndonesiaDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, IndonesiaAutoimmune disease is a chronic condition that requires treatment with prolonged use of drugs. Consequently, there is a significant occurrence of adverse effects and toxicity associated with the medicine. On the other hand, epigallocatechin gallate (EGCG), the primary bioactive catechin in green tea (Camellia sinensis), has been demonstrated to possess anti-inflammatory properties and exhibit therapeutic effects in autoimmune disorders. Therefore, EGCG can be considered a complementary and alternative medicine to address the limitations of current treatment. Turning to the disease pathology, the balance between helper T-cell (Th) and regulatory T-cell (Treg) differentiation is the crucial aspect that needs to be regulated in order to attain immunological tolerance and suppress the incidence and severity of autoimmune disease. Here, we aim to comprehensively review the immunomodulatory effect of EGCG on the balance of Th/Treg cell differentiation in diverse autoimmune disorders. Scientific databases, including Scopus, PubMed, Science Direct, and Google Scholar, were searched using the keywords autoimmune AND (epigallocatechin-3-gallate OR epigallocatechin gallate OR EGCG) AND (Thelper OR Th OR Treg OR CD4). Our review revealed that EGCG has ability to repair the imbalance of Th/Treg cell differentiation in rheumatoid arthritis (RA), multiple sclerosis (MS), ulcerative colitis (UC), and autoimmune uveitis (AU) by inhibiting the differentiation of Th1 and Th17 cells while promoting the differentiation of Th2 and Treg cells, as well as improving the clinical conditions of the tested animals. Hence, it might be inferred that EGCG exhibits considerable promise as a viable complementary and alternative therapeutic option for autoimmune disease.https://herbmedpharmacol.com/PDF/jhp-13-176.pdfteacatechinmedicinal plantmedicinal plantdrug discovery |
| spellingShingle | Vigha Ilmanafi Arifka Andayana Puspitasari Gani Retno Murwanti Epigallocatechin gallate, the primary bioactive component from Camellia sinensis: A review on immunomodulatory effects in autoimmune diseases by balancing the differentiation of Th and Treg cells Journal of HerbMed Pharmacology tea catechin medicinal plant medicinal plant drug discovery |
| title | Epigallocatechin gallate, the primary bioactive component from Camellia sinensis: A review on immunomodulatory effects in autoimmune diseases by balancing the differentiation of Th and Treg cells |
| title_full | Epigallocatechin gallate, the primary bioactive component from Camellia sinensis: A review on immunomodulatory effects in autoimmune diseases by balancing the differentiation of Th and Treg cells |
| title_fullStr | Epigallocatechin gallate, the primary bioactive component from Camellia sinensis: A review on immunomodulatory effects in autoimmune diseases by balancing the differentiation of Th and Treg cells |
| title_full_unstemmed | Epigallocatechin gallate, the primary bioactive component from Camellia sinensis: A review on immunomodulatory effects in autoimmune diseases by balancing the differentiation of Th and Treg cells |
| title_short | Epigallocatechin gallate, the primary bioactive component from Camellia sinensis: A review on immunomodulatory effects in autoimmune diseases by balancing the differentiation of Th and Treg cells |
| title_sort | epigallocatechin gallate the primary bioactive component from camellia sinensis a review on immunomodulatory effects in autoimmune diseases by balancing the differentiation of th and treg cells |
| topic | tea catechin medicinal plant medicinal plant drug discovery |
| url | https://herbmedpharmacol.com/PDF/jhp-13-176.pdf |
| work_keys_str_mv | AT vighailmanafiarifka epigallocatechingallatetheprimarybioactivecomponentfromcamelliasinensisareviewonimmunomodulatoryeffectsinautoimmunediseasesbybalancingthedifferentiationofthandtregcells AT andayanapuspitasarigani epigallocatechingallatetheprimarybioactivecomponentfromcamelliasinensisareviewonimmunomodulatoryeffectsinautoimmunediseasesbybalancingthedifferentiationofthandtregcells AT retnomurwanti epigallocatechingallatetheprimarybioactivecomponentfromcamelliasinensisareviewonimmunomodulatoryeffectsinautoimmunediseasesbybalancingthedifferentiationofthandtregcells |