Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity

Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity

BackgroundType 1 Diabetes (T1D) is caused by a combination of genetic and environmental factors that trigger autoimmune-mediated destruction of pancreatic β-cells. Defects in β-cell stress response pathways such as autophagy may play an important role in activating and/or exacerbating the immune res...

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Bibliographic Details
Main Authors: Matthew C. Austin, Charanya Muralidharan, Saptarshi Roy, Justin J. Crowder, Jon D. Piganelli, Amelia K. Linnemann
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
autophagy
β-cell stress
islet immunogenicity
HLA-I expression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1504583/full
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