Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility
Objective To investigate the effects of light fasting diet therapy, including flaxseed powder supplementation, on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome (PCOS) combined with infertility.Methods A total of 104 PCOS patients with combined infertility were di...
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Taylor & Francis Group
2025-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2025.2458084 |
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| author | Xiaomei Jiang Yongfeng Wang Hong Tang Jin Ma Heyue Li |
| author_facet | Xiaomei Jiang Yongfeng Wang Hong Tang Jin Ma Heyue Li |
| author_sort | Xiaomei Jiang |
| collection | DOAJ |
| description | Objective To investigate the effects of light fasting diet therapy, including flaxseed powder supplementation, on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome (PCOS) combined with infertility.Methods A total of 104 PCOS patients with combined infertility were divided into the control group (n = 52) and intervention group (n = 52) using a random number table method. Over a two-month study period, the control group received light fasting diet therapy with rice flour as a placebo, while the intervention group received light fasting diet therapy supplemented with flaxseed powder. Differences in general clinical data, anthropometric indicators, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), fasting plasma glucose (FPG), fasting insulin (FINS), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)) were compared between the two groups.Results After treatment, both groups showed significant reductions in FSH, LH, E2, and P levels compared to baseline (p < .05). In the intervention group, the mean FINS and HOMA-IR levels were significantly lower than those in the control group following 2 months of treatment (p < .05). Furthermore, TC, TG, and LDL-C levels were significantly reduced in the intervention group compared to the control group (p < .05).Conclusion Light fasting diet therapy, especially with flaxseed powder, improves obesity, lipid, and glucose metabolism disorders in PCOS patients with infertility. However, longitudinal studies are needed to better understand these associations and assess long-term effects before considering this intervention as a standard clinical recommendation for PCOS. |
| format | Article |
| id | doaj-art-6161b86aa29944c3b30828c8a89b98bf |
| institution | Kabale University |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gynecological Endocrinology |
| spelling | doaj-art-6161b86aa29944c3b30828c8a89b98bf2025-01-29T13:03:25ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662025-12-0141110.1080/09513590.2025.2458084Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertilityXiaomei Jiang0Yongfeng Wang1Hong Tang2Jin Ma3Heyue Li4Department of Gynecology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Gynecology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Gynecology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Gynecology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Gynecology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaObjective To investigate the effects of light fasting diet therapy, including flaxseed powder supplementation, on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome (PCOS) combined with infertility.Methods A total of 104 PCOS patients with combined infertility were divided into the control group (n = 52) and intervention group (n = 52) using a random number table method. Over a two-month study period, the control group received light fasting diet therapy with rice flour as a placebo, while the intervention group received light fasting diet therapy supplemented with flaxseed powder. Differences in general clinical data, anthropometric indicators, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), fasting plasma glucose (FPG), fasting insulin (FINS), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)) were compared between the two groups.Results After treatment, both groups showed significant reductions in FSH, LH, E2, and P levels compared to baseline (p < .05). In the intervention group, the mean FINS and HOMA-IR levels were significantly lower than those in the control group following 2 months of treatment (p < .05). Furthermore, TC, TG, and LDL-C levels were significantly reduced in the intervention group compared to the control group (p < .05).Conclusion Light fasting diet therapy, especially with flaxseed powder, improves obesity, lipid, and glucose metabolism disorders in PCOS patients with infertility. However, longitudinal studies are needed to better understand these associations and assess long-term effects before considering this intervention as a standard clinical recommendation for PCOS.https://www.tandfonline.com/doi/10.1080/09513590.2025.2458084Light fasting diet therapyinfertilityPCOSlipid metabolism |
| spellingShingle | Xiaomei Jiang Yongfeng Wang Hong Tang Jin Ma Heyue Li Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility Gynecological Endocrinology Light fasting diet therapy infertility PCOS lipid metabolism |
| title | Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility |
| title_full | Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility |
| title_fullStr | Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility |
| title_full_unstemmed | Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility |
| title_short | Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility |
| title_sort | effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility |
| topic | Light fasting diet therapy infertility PCOS lipid metabolism |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2025.2458084 |
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