Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers?
Background. Adrenocortical carcinoma (ACC) is a rare and aggressive tumor arising from the adrenal cortex with an incidence of one to two cases per million within the general US population. Recent developments in the understanding of the pathogenesis of ACC have led to multiple clinical trials invol...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/875764 |
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| _version_ | 1832545438441406464 |
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| author | M. W. Saif B. Fallon K. N. Syrigos |
| author_facet | M. W. Saif B. Fallon K. N. Syrigos |
| author_sort | M. W. Saif |
| collection | DOAJ |
| description | Background. Adrenocortical carcinoma (ACC) is a rare and aggressive tumor arising from the adrenal cortex with an incidence of one to two cases per million within the general US population. Recent developments in the understanding of the pathogenesis of ACC have led to multiple clinical trials involving targeted agents in the management of ACC.
Patients and Methods. We report two cases of refractory adrenocortical cancer (cisplatin, adriamycin, etoposide, and mitotane) who were treated with targeted agents such as erlotinib and sutent, respectively. A total of 2 women with adrenocortical cancer were reviewed and followed for a median time of 6 months. Radiological response, duration of response and toxicities were evaluated. Results. In both cases, the targeted agents were able to control the disease for a short duration, but due to the deterioration in performance status and fatigue the agents were discontinued. Conclusion. The current observations emphasize the need for better targeted treatment modalities and strategies for the management of this fatal disease. |
| format | Article |
| id | doaj-art-615634338ad94868891515a9f8e2ad75 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-615634338ad94868891515a9f8e2ad752025-02-03T07:25:45ZengWileyCase Reports in Endocrinology2090-65012090-651X2012-01-01201210.1155/2012/875764875764Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers?M. W. Saif0B. Fallon1K. N. Syrigos2Division of Hematology/Oncology, Tufts Medical Center, Tufts University School of Medicine, MA, USAThe Hospital of Central Connecticut, New Britain, CT 06489, USAOncology Unit GPP, Sotiria General Hospital, Athens School of Medicine, Mesogeion 152, 115 27 Athens, GreeceBackground. Adrenocortical carcinoma (ACC) is a rare and aggressive tumor arising from the adrenal cortex with an incidence of one to two cases per million within the general US population. Recent developments in the understanding of the pathogenesis of ACC have led to multiple clinical trials involving targeted agents in the management of ACC. Patients and Methods. We report two cases of refractory adrenocortical cancer (cisplatin, adriamycin, etoposide, and mitotane) who were treated with targeted agents such as erlotinib and sutent, respectively. A total of 2 women with adrenocortical cancer were reviewed and followed for a median time of 6 months. Radiological response, duration of response and toxicities were evaluated. Results. In both cases, the targeted agents were able to control the disease for a short duration, but due to the deterioration in performance status and fatigue the agents were discontinued. Conclusion. The current observations emphasize the need for better targeted treatment modalities and strategies for the management of this fatal disease.http://dx.doi.org/10.1155/2012/875764 |
| spellingShingle | M. W. Saif B. Fallon K. N. Syrigos Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? Case Reports in Endocrinology |
| title | Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? |
| title_full | Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? |
| title_fullStr | Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? |
| title_full_unstemmed | Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? |
| title_short | Is There a Role of Targeted Agents in the Management of Adrenocortical Cancers? |
| title_sort | is there a role of targeted agents in the management of adrenocortical cancers |
| url | http://dx.doi.org/10.1155/2012/875764 |
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