Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology
Nanodrug delivery systems (NDDSs) have demonstrated broad application prospects in disease treatment, prevention, and diagnosis due to their nanoscale size advantages and high drug-loading capacity. However, their clinical translation still faces multiple challenges, including rapid clearance by the...
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| Language: | English |
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Elsevier
2025-08-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425004922 |
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| author | Yuyan Zhou Xinyue Wang Xiaorong Tian Deyu Zhang Hanxiao Cui Wei Du Zhenghui Yang Jiayu Li Wanshun Li Jiaheng Xu Ying Duanmu Ting Yu Fengping Cai Wenhao Li Zhendong Jin Wencheng Wu Haojie Huang |
| author_facet | Yuyan Zhou Xinyue Wang Xiaorong Tian Deyu Zhang Hanxiao Cui Wei Du Zhenghui Yang Jiayu Li Wanshun Li Jiaheng Xu Ying Duanmu Ting Yu Fengping Cai Wenhao Li Zhendong Jin Wencheng Wu Haojie Huang |
| author_sort | Yuyan Zhou |
| collection | DOAJ |
| description | Nanodrug delivery systems (NDDSs) have demonstrated broad application prospects in disease treatment, prevention, and diagnosis due to their nanoscale size advantages and high drug-loading capacity. However, their clinical translation still faces multiple challenges, including rapid clearance by the reticuloendothelial system (RES), nonspecific targeting, and insufficient efficiency in crossing biological barriers. Cell membrane-coated biomimetic delivery systems (CMC-BDS), which integrates natural cell membranes onto nanoparticle (NPs) surfaces, provides nanodrugs with a versatile ''biomimetic cloak,'' representing a highly promising surface engineering strategy. This approach enables nanocarriers to inherit the intrinsic biological properties of different cell sources, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, and biodegradability, while supporting the integration of diverse biomedical functions. Furthermore, surface functionalization modifications can enhance their programmability, multifunctionality, and biointerface adaptability, thereby optimizing targeted delivery efficiency and extending in vivo circulation time. This review first outlines the development and key preparation steps of cell membrane coating technology. It then discusses the selection strategies for various cell membrane types—including leukocyte, erythrocyte, platelet, dendritic cell, tumor cell, and bacterial membranes—while comparing their respective advantages and limitations. Finally, the review highlights recent advances in applying cell membrane-coated nanoparticles (CMC-NPs) for treating tumors, ischemic stroke, and inflammatory diseases. |
| format | Article |
| id | doaj-art-6154f099c7674a0aa2a96e92e13b4f17 |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-6154f099c7674a0aa2a96e92e13b4f172025-08-20T02:31:08ZengElsevierMaterials Today Bio2590-00642025-08-013310192210.1016/j.mtbio.2025.101922Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technologyYuyan Zhou0Xinyue Wang1Xiaorong Tian2Deyu Zhang3Hanxiao Cui4Wei Du5Zhenghui Yang6Jiayu Li7Wanshun Li8Jiaheng Xu9Ying Duanmu10Ting Yu11Fengping Cai12Wenhao Li13Zhendong Jin14Wencheng Wu15Haojie Huang16Department of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, ChinaDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, ChinaDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, ChinaDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, ChinaDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, ChinaDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, ChinaDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, ChinaDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, ChinaDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, ChinaDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, ChinaDepartment of Plastic Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, ChinaDepartment of Geriatric Medicine, Fujian Provincial Center for Geriatrics, Provincial Hospital Affiliated to Fuzhou University, Fuzhou, 350001, Fujian Province, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian Province, ChinaCentral Laboratory and Department of Medical Ultrasound, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan Province, China; Corresponding authors.Department of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China; Corresponding author.Central Laboratory and Department of Medical Ultrasound, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan Province, China; Corresponding authors.Department of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai, 200433, China; Corresponding author.Nanodrug delivery systems (NDDSs) have demonstrated broad application prospects in disease treatment, prevention, and diagnosis due to their nanoscale size advantages and high drug-loading capacity. However, their clinical translation still faces multiple challenges, including rapid clearance by the reticuloendothelial system (RES), nonspecific targeting, and insufficient efficiency in crossing biological barriers. Cell membrane-coated biomimetic delivery systems (CMC-BDS), which integrates natural cell membranes onto nanoparticle (NPs) surfaces, provides nanodrugs with a versatile ''biomimetic cloak,'' representing a highly promising surface engineering strategy. This approach enables nanocarriers to inherit the intrinsic biological properties of different cell sources, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, and biodegradability, while supporting the integration of diverse biomedical functions. Furthermore, surface functionalization modifications can enhance their programmability, multifunctionality, and biointerface adaptability, thereby optimizing targeted delivery efficiency and extending in vivo circulation time. This review first outlines the development and key preparation steps of cell membrane coating technology. It then discusses the selection strategies for various cell membrane types—including leukocyte, erythrocyte, platelet, dendritic cell, tumor cell, and bacterial membranes—while comparing their respective advantages and limitations. Finally, the review highlights recent advances in applying cell membrane-coated nanoparticles (CMC-NPs) for treating tumors, ischemic stroke, and inflammatory diseases.http://www.sciencedirect.com/science/article/pii/S2590006425004922Cell membrane-coated nanoparticles (CMC-NPs)Cell membrane-coated biomimetic delivery systems (CMC-BDS)Immune evasionDynamic targetingTumor therapyIschemic stroke |
| spellingShingle | Yuyan Zhou Xinyue Wang Xiaorong Tian Deyu Zhang Hanxiao Cui Wei Du Zhenghui Yang Jiayu Li Wanshun Li Jiaheng Xu Ying Duanmu Ting Yu Fengping Cai Wenhao Li Zhendong Jin Wencheng Wu Haojie Huang Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology Materials Today Bio Cell membrane-coated nanoparticles (CMC-NPs) Cell membrane-coated biomimetic delivery systems (CMC-BDS) Immune evasion Dynamic targeting Tumor therapy Ischemic stroke |
| title | Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology |
| title_full | Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology |
| title_fullStr | Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology |
| title_full_unstemmed | Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology |
| title_short | Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology |
| title_sort | stealth missiles with precision guidance a novel multifunctional nano drug delivery system based on biomimetic cell membrane coating technology |
| topic | Cell membrane-coated nanoparticles (CMC-NPs) Cell membrane-coated biomimetic delivery systems (CMC-BDS) Immune evasion Dynamic targeting Tumor therapy Ischemic stroke |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425004922 |
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