TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients
Aim: Although the predictive and prognostic value of thymidylate synthase (TS) expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphis...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.3233/ACP-CLO-2010-0526 |
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| author | A. Fariña-Sarasqueta M. J. E. M. Gosens E. Moerland I. van Lijnschoten V. E. P. P. Lemmens G. D. Slooter H. J. T. Rutten A. J. C. van den Brule |
| author_facet | A. Fariña-Sarasqueta M. J. E. M. Gosens E. Moerland I. van Lijnschoten V. E. P. P. Lemmens G. D. Slooter H. J. T. Rutten A. J. C. van den Brule |
| author_sort | A. Fariña-Sarasqueta |
| collection | DOAJ |
| description | Aim: Although the predictive and prognostic value of thymidylate synthase (TS) expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphisms genotyping in therapy response in stage III colon carcinoma patients treated with 5-FU adjuvant chemotherapy. |
| format | Article |
| id | doaj-art-615434059e2b4ace8b987a6aee8edfe7 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-615434059e2b4ace8b987a6aee8edfe72025-02-03T05:52:44ZengWileyAnalytical Cellular Pathology2210-71772210-71852010-01-0133111110.3233/ACP-CLO-2010-0526TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer PatientsA. Fariña-Sarasqueta0M. J. E. M. Gosens1E. Moerland2I. van Lijnschoten3V. E. P. P. Lemmens4G. D. Slooter5H. J. T. Rutten6A. J. C. van den Brule7PAMM Laboratory for Pathology, Eindhoven, The NetherlandsFontys University of Applied Science, Centre for Medical Molecular Diagnostics, Eindhoven, The NetherlandsPAMM Laboratory for Pathology, Eindhoven, The NetherlandsPAMM Laboratory for Pathology, Eindhoven, The NetherlandsComprehensive Cancer Centre South, Eindhoven, The NetherlandsDepartment of Surgery, Máxima Medical Centre Veldhoven, Veldhoven, The NetherlandsDepartment of Surgical Oncology, Catharina Hospital Eindhoven, Eindhoven, The NetherlandsPAMM Laboratory for Pathology, Eindhoven, The NetherlandsAim: Although the predictive and prognostic value of thymidylate synthase (TS) expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphisms genotyping in therapy response in stage III colon carcinoma patients treated with 5-FU adjuvant chemotherapy.http://dx.doi.org/10.3233/ACP-CLO-2010-0526 |
| spellingShingle | A. Fariña-Sarasqueta M. J. E. M. Gosens E. Moerland I. van Lijnschoten V. E. P. P. Lemmens G. D. Slooter H. J. T. Rutten A. J. C. van den Brule TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients Analytical Cellular Pathology |
| title | TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients |
| title_full | TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients |
| title_fullStr | TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients |
| title_full_unstemmed | TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients |
| title_short | TS Gene Polymorphisms Are Not Good Markers of Response to 5-FU Therapy in Stage III Colon Cancer Patients |
| title_sort | ts gene polymorphisms are not good markers of response to 5 fu therapy in stage iii colon cancer patients |
| url | http://dx.doi.org/10.3233/ACP-CLO-2010-0526 |
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