Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus
Previous Gestational Diabetes Mellitus (pGDM) is a common condition and has been associated with future development of Type 2 Diabetes Mellitus (T2DM) and Metabolic Syndrome (MS) in women affected. The pathogenesis and risk factors implicated in the development of these conditions later in the lives...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/549748 |
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| author | Nikolaos Vrachnis Panagiotis Belitsos Stavros Sifakis Konstantinos Dafopoulos Charalambos Siristatidis Kalliopi I. Pappa Zoe Iliodromiti |
| author_facet | Nikolaos Vrachnis Panagiotis Belitsos Stavros Sifakis Konstantinos Dafopoulos Charalambos Siristatidis Kalliopi I. Pappa Zoe Iliodromiti |
| author_sort | Nikolaos Vrachnis |
| collection | DOAJ |
| description | Previous Gestational Diabetes Mellitus (pGDM) is a common condition and has been associated with future development of Type 2 Diabetes Mellitus (T2DM) and Metabolic Syndrome (MS) in women affected. The pathogenesis and risk factors implicated in the development of these conditions later in the lives of women with pGDM are not as yet fully understood. Research has recently focused on a group of substances produced mainly by adipose tissue called adipokines, this group including, among others, adiponectin, leptin, Retinol-Binding Protein-4 (RBP-4), and resistin. These substances as well as other inflammatory mediators (CRP, IL-6, PAI-1, TNF-α) seem to play an important role in glucose tolerance and insulin sensitivity dysregulation in women with pGDM. We summarize the data available on the role of these molecules. |
| format | Article |
| id | doaj-art-6152ac4ee2b64ad0b7172788290203e9 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6152ac4ee2b64ad0b7172788290203e92025-02-03T06:08:21ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/549748549748Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes MellitusNikolaos Vrachnis0Panagiotis Belitsos1Stavros Sifakis2Konstantinos Dafopoulos3Charalambos Siristatidis4Kalliopi I. Pappa5Zoe Iliodromiti62nd Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieio Hospital, 11528 Athens, GreeceDepartment of Obstetrics and Gynaecology, General Hospital of Chalkida, Evia, Chalkida 34100, GreeceDepartment of Obstetrics and Gynaecology, University Hospital of Heraklion, 71110 Heraklio, Crete, GreeceDepartment of Obstetrics and Gynaecology, Medical School, University of Thessaly, 41334 Larissa, Greece3rd Department of Obstetrics and Gynecology, University of Athens, 12462 Athens, Greece1st Department of Obstetrics and Gynecology, University of Athens, School of Medicine, Athens, Greece2nd Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieio Hospital, 11528 Athens, GreecePrevious Gestational Diabetes Mellitus (pGDM) is a common condition and has been associated with future development of Type 2 Diabetes Mellitus (T2DM) and Metabolic Syndrome (MS) in women affected. The pathogenesis and risk factors implicated in the development of these conditions later in the lives of women with pGDM are not as yet fully understood. Research has recently focused on a group of substances produced mainly by adipose tissue called adipokines, this group including, among others, adiponectin, leptin, Retinol-Binding Protein-4 (RBP-4), and resistin. These substances as well as other inflammatory mediators (CRP, IL-6, PAI-1, TNF-α) seem to play an important role in glucose tolerance and insulin sensitivity dysregulation in women with pGDM. We summarize the data available on the role of these molecules.http://dx.doi.org/10.1155/2012/549748 |
| spellingShingle | Nikolaos Vrachnis Panagiotis Belitsos Stavros Sifakis Konstantinos Dafopoulos Charalambos Siristatidis Kalliopi I. Pappa Zoe Iliodromiti Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus International Journal of Endocrinology |
| title | Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus |
| title_full | Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus |
| title_fullStr | Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus |
| title_full_unstemmed | Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus |
| title_short | Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus |
| title_sort | role of adipokines and other inflammatory mediators in gestational diabetes mellitus and previous gestational diabetes mellitus |
| url | http://dx.doi.org/10.1155/2012/549748 |
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