PPARs: Protectors or Opponents of Myocardial Function?
Over 5 million people in the United States suffer from the complications of heart failure (HF), which is a rapidly expanding health complication. Disorders that contribute to HF include ischemic cardiac disease, cardiomyopathies, and hypertension. Peroxisome proliferator-activated receptors (PPARs)...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2015/835985 |
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| author | Christine J. Pol Melissa Lieu Konstantinos Drosatos |
| author_facet | Christine J. Pol Melissa Lieu Konstantinos Drosatos |
| author_sort | Christine J. Pol |
| collection | DOAJ |
| description | Over 5 million people in the United States suffer from the complications of heart failure (HF), which is a rapidly expanding health complication. Disorders that contribute to HF include ischemic cardiac disease, cardiomyopathies, and hypertension. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family. There are three PPAR isoforms: PPARα, PPARγ, and PPARδ. They can be activated by endogenous ligands, such as fatty acids, as well as by pharmacologic agents. Activators of PPARs are used for treating several metabolic complications, such as diabetes and hyperlipidemia that are directly or indirectly associated with HF. However, some of these drugs have adverse effects that compromise cardiac function. This review article aims to summarize the current basic and clinical research findings of the beneficial or detrimental effects of PPAR biology on myocardial function. |
| format | Article |
| id | doaj-art-614a5c09e70649a68dac710eb3b1c2f2 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-614a5c09e70649a68dac710eb3b1c2f22025-02-03T05:45:59ZengWileyPPAR Research1687-47571687-47652015-01-01201510.1155/2015/835985835985PPARs: Protectors or Opponents of Myocardial Function?Christine J. Pol0Melissa Lieu1Konstantinos Drosatos2Temple University School of Medicine, Department of Pharmacology, Center for Translational Medicine, Philadelphia, PA 19140, USATemple University School of Medicine, Department of Pharmacology, Center for Translational Medicine, Philadelphia, PA 19140, USATemple University School of Medicine, Department of Pharmacology, Center for Translational Medicine, Philadelphia, PA 19140, USAOver 5 million people in the United States suffer from the complications of heart failure (HF), which is a rapidly expanding health complication. Disorders that contribute to HF include ischemic cardiac disease, cardiomyopathies, and hypertension. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family. There are three PPAR isoforms: PPARα, PPARγ, and PPARδ. They can be activated by endogenous ligands, such as fatty acids, as well as by pharmacologic agents. Activators of PPARs are used for treating several metabolic complications, such as diabetes and hyperlipidemia that are directly or indirectly associated with HF. However, some of these drugs have adverse effects that compromise cardiac function. This review article aims to summarize the current basic and clinical research findings of the beneficial or detrimental effects of PPAR biology on myocardial function.http://dx.doi.org/10.1155/2015/835985 |
| spellingShingle | Christine J. Pol Melissa Lieu Konstantinos Drosatos PPARs: Protectors or Opponents of Myocardial Function? PPAR Research |
| title | PPARs: Protectors or Opponents of Myocardial Function? |
| title_full | PPARs: Protectors or Opponents of Myocardial Function? |
| title_fullStr | PPARs: Protectors or Opponents of Myocardial Function? |
| title_full_unstemmed | PPARs: Protectors or Opponents of Myocardial Function? |
| title_short | PPARs: Protectors or Opponents of Myocardial Function? |
| title_sort | ppars protectors or opponents of myocardial function |
| url | http://dx.doi.org/10.1155/2015/835985 |
| work_keys_str_mv | AT christinejpol pparsprotectorsoropponentsofmyocardialfunction AT melissalieu pparsprotectorsoropponentsofmyocardialfunction AT konstantinosdrosatos pparsprotectorsoropponentsofmyocardialfunction |