Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report
An elderly woman was admitted with the chief complaint of gross hematuria. Laboratory values indicated a high myeloperoxidase-ANCA level. In renal histological examination, 40% of the glomeruli showed crescent formation, but immunofluorescence staining showed positivity for IgG, C3, and C1q. Further...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2020/6343521 |
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| author | Tomohiko Asakawa Mea Asou Shigeo Hara Takashi Ehara Makoto Araki |
| author_facet | Tomohiko Asakawa Mea Asou Shigeo Hara Takashi Ehara Makoto Araki |
| author_sort | Tomohiko Asakawa |
| collection | DOAJ |
| description | An elderly woman was admitted with the chief complaint of gross hematuria. Laboratory values indicated a high myeloperoxidase-ANCA level. In renal histological examination, 40% of the glomeruli showed crescent formation, but immunofluorescence staining showed positivity for IgG, C3, and C1q. Furthermore, the deposition of fibrils in the glomerulus was noted on electron microscopy, and immunohistochemical staining showed strong positivity for DNA-J heat shock protein family member B9 (DNAJB9). Crescent formation is a common feature of fibrillary glomerulonephritis (FGN). Thus, in ANCA-positive crescentic glomerulonephritis, immunohistochemical assessments for immunoglobulins and DNAJB9, as well as electron microscopy, are important to correctly diagnose FGN. |
| format | Article |
| id | doaj-art-6147219c38774990a81fedc84ff4c71f |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-6147219c38774990a81fedc84ff4c71f2025-02-03T01:05:17ZengWileyCase Reports in Nephrology2090-66412090-665X2020-01-01202010.1155/2020/63435216343521Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case ReportTomohiko Asakawa0Mea Asou1Shigeo Hara2Takashi Ehara3Makoto Araki4Department of Internal Medicine, Suwa Central Hospital, Chino, Nagano 391-8503, JapanDepartment of Internal Medicine, Suwa Central Hospital, Chino, Nagano 391-8503, JapanDepartment of Diagnostic Pathology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima Minamimachi, Chuo-ku, Kobe 650-0047, JapanGraduate School of Health Sciences, Matsumoto University, 2095-1 Niimura, Matsumoto 390-1241, JapanDepartment of Internal Medicine, Suwa Central Hospital, Chino, Nagano 391-8503, JapanAn elderly woman was admitted with the chief complaint of gross hematuria. Laboratory values indicated a high myeloperoxidase-ANCA level. In renal histological examination, 40% of the glomeruli showed crescent formation, but immunofluorescence staining showed positivity for IgG, C3, and C1q. Furthermore, the deposition of fibrils in the glomerulus was noted on electron microscopy, and immunohistochemical staining showed strong positivity for DNA-J heat shock protein family member B9 (DNAJB9). Crescent formation is a common feature of fibrillary glomerulonephritis (FGN). Thus, in ANCA-positive crescentic glomerulonephritis, immunohistochemical assessments for immunoglobulins and DNAJB9, as well as electron microscopy, are important to correctly diagnose FGN.http://dx.doi.org/10.1155/2020/6343521 |
| spellingShingle | Tomohiko Asakawa Mea Asou Shigeo Hara Takashi Ehara Makoto Araki Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report Case Reports in Nephrology |
| title | Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report |
| title_full | Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report |
| title_fullStr | Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report |
| title_full_unstemmed | Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report |
| title_short | Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report |
| title_sort | fibrillary glomerulopathy with a high level of myeloperoxidase anca a case report |
| url | http://dx.doi.org/10.1155/2020/6343521 |
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