Effect of Cumulative Exposure on the Efficacy of Paroxetine: A Population Pharmacokinetic‐Pharmacodynamic and Machine Learning Analyses

Effect of Cumulative Exposure on the Efficacy of Paroxetine: A Population Pharmacokinetic‐Pharmacodynamic and Machine Learning Analyses

ABSTRACT Selective serotonin reuptake inhibitors (SSRIs) are widely used in depression treatment. However, the relationship between treatment efficacy and plasma concentrations remains unclear. We assessed whether the anti‐depressive response can be predicted based on the pharmacokinetic (PK) data o...

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Main Authors: Keiichi Shigetome, Tomoko Egashira, Tetsu Tomita, Nagisa Higa, Kazuma Iwashita, Kazuya Morita, Miki Nishimura, Tetsuya Kaneko, Hitoshi Maeda, Kazunori D. Yamada, Ayami Kajiwara‐Morita, Kentaro Oniki, Norio Yasui‐Furukori, Junji Saruwatari
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Subjects:
area under the curve
depression
exposure response
mathematical modeling
pharmacokinetics‐pharmacodynamics
precision medicine
Online Access:https://doi.org/10.1002/psp4.70032
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https://doi.org/10.1002/psp4.70032

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