A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels
Background. To examine the association between low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels and liver enzyme functions. Methods. The National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2012 was used to examine the association between liver enzymes a...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/1286170 |
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| author | Subrata Deb Prasanth Puthanveetil Prashant Sakharkar |
| author_facet | Subrata Deb Prasanth Puthanveetil Prashant Sakharkar |
| author_sort | Subrata Deb |
| collection | DOAJ |
| description | Background. To examine the association between low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels and liver enzyme functions. Methods. The National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2012 was used to examine the association between liver enzymes and lipid levels amongst adults in the United States. Results. Sixteen percent adults had ALT > 40 U/L, 11% had AST > 40 U/L, and 96% had ALP > 120 U/L. Age, gender, and race/ethnicity showed significant association with LDL, HDL, and triglycerides levels. LDL greater than borderline high was associated with little over two times higher odds of elevated ALT (OR: 2.33, 95% CI: 2.17, 2.53, p≤0.001) and AST (OR: 2.79, 95% CI: 2.55, 3.06, p≤0.001). High HDL was associated with 50% higher odds for elevated ALT (OR: 1.51, 95% CI: 1.39, 1.64, p≤0.001) and over two-and-half fold elevated AST (OR: 2.77, 95% CI: 2.47, 3.11, p≤0.001). LDL-C, HDL-C, and triglycerides were found to be good predictor of elevated ALT, AST, and ALP levels. Similarly, old age and female gender were significant predictor of elevated ALT and AST (p≤0.001). Conclusions. Underlying hepatic pathophysiology from dyslipidemia deserves further exploration due to its potential effects on hepatic drug metabolism/detoxification. |
| format | Article |
| id | doaj-art-613a1998067e4c269f439a0075827056 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-613a1998067e4c269f439a00758270562025-02-03T01:26:08ZengWileyInternational Journal of Hepatology2090-34482090-34562018-01-01201810.1155/2018/12861701286170A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid LevelsSubrata Deb0Prasanth Puthanveetil1Prashant Sakharkar2Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USARoosevelt University College of Pharmacy, Schaumburg, IL 60173, USARoosevelt University College of Pharmacy, Schaumburg, IL 60173, USABackground. To examine the association between low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels and liver enzyme functions. Methods. The National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2012 was used to examine the association between liver enzymes and lipid levels amongst adults in the United States. Results. Sixteen percent adults had ALT > 40 U/L, 11% had AST > 40 U/L, and 96% had ALP > 120 U/L. Age, gender, and race/ethnicity showed significant association with LDL, HDL, and triglycerides levels. LDL greater than borderline high was associated with little over two times higher odds of elevated ALT (OR: 2.33, 95% CI: 2.17, 2.53, p≤0.001) and AST (OR: 2.79, 95% CI: 2.55, 3.06, p≤0.001). High HDL was associated with 50% higher odds for elevated ALT (OR: 1.51, 95% CI: 1.39, 1.64, p≤0.001) and over two-and-half fold elevated AST (OR: 2.77, 95% CI: 2.47, 3.11, p≤0.001). LDL-C, HDL-C, and triglycerides were found to be good predictor of elevated ALT, AST, and ALP levels. Similarly, old age and female gender were significant predictor of elevated ALT and AST (p≤0.001). Conclusions. Underlying hepatic pathophysiology from dyslipidemia deserves further exploration due to its potential effects on hepatic drug metabolism/detoxification.http://dx.doi.org/10.1155/2018/1286170 |
| spellingShingle | Subrata Deb Prasanth Puthanveetil Prashant Sakharkar A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels International Journal of Hepatology |
| title | A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels |
| title_full | A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels |
| title_fullStr | A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels |
| title_full_unstemmed | A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels |
| title_short | A Population-Based Cross-Sectional Study of the Association between Liver Enzymes and Lipid Levels |
| title_sort | population based cross sectional study of the association between liver enzymes and lipid levels |
| url | http://dx.doi.org/10.1155/2018/1286170 |
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